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Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction

Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral (CL) does not. In this study we investigated the effect of UUO on gene express...

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Detalles Bibliográficos
Autores principales:	Tveitarås, Maria K., Skogstrand, Trude, Leh, Sabine, Helle, Frank, Iversen, Bjarne M., Chatziantoniou, Christos, Reed, Rolf K., Hultström, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687651/ https://www.ncbi.nlm.nih.gov/pubmed/26673451 http://dx.doi.org/10.1371/journal.pone.0143390

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