Cargando…

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a nov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reppe, Sjur, Wang, Yunpeng, Thompson, Wesley K., McEvoy, Linda K., Schork, Andrew J., Zuber, Verena, LeBlanc, Marissa, Bettella, Francesco, Mills, Ian G., Desikan, Rahul S., Djurovic, Srdjan, Gautvik, Kaare M., Dale, Anders M., Andreassen, Ole A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687843/ https://www.ncbi.nlm.nih.gov/pubmed/26695485 http://dx.doi.org/10.1371/journal.pone.0144531

Ejemplares similares

The Influence of DNA Methylation on Bone Cells
por: Reppe, Sjur, et al.
Publicado: (2015)

Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
por: Andreassen, Ole A., et al.
Publicado: (2015)

Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms
por: Andreassen, Ole A., et al.
Publicado: (2015)

MicroRNAs enrichment in GWAS of complex human phenotypes
por: Goulart, Luiz F, et al.
Publicado: (2015)

Probing the Association between Early Evolutionary Markers and Schizophrenia
por: Srinivasan, Saurabh, et al.
Publicado: (2017)

Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
por: Andreassen, O A, et al.
Publicado: (2015)

Identification of shared genetic variants between schizophrenia and lung cancer
por: Zuber, Verena, et al.
Publicado: (2018)

Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study
por: Olstad, Ole Kristoffer, et al.
Publicado: (2020)

Cross-tissue eQTL enrichment of associations in schizophrenia
por: Bettella, Francesco, et al.
Publicado: (2018)

Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women
por: Lien, Tonje G., et al.
Publicado: (2018)

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer
por: Zuber, Verena, et al.
Publicado: (2017)

Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling
por: Varanasi, Satya S., et al.
Publicado: (2010)

Enrichment of genetic markers of recent human evolution in educational and cognitive traits
por: Srinivasan, Saurabh, et al.
Publicado: (2018)

Lipocalin 2 serum levels correlate with age and bone turnover biomarkers in healthy subjects but not in postmenopausal osteoporotic women
por: Maurizi, Antonio, et al.
Publicado: (2021)

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework
por: LeBlanc, Marissa, et al.
Publicado: (2018)

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS
por: Wang, Yunpeng, et al.
Publicado: (2016)

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate
por: Andreassen, Ole A., et al.
Publicado: (2013)

Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate
por: Andreassen, Ole A., et al.
Publicado: (2015)

Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders
por: Haram, Marit, et al.
Publicado: (2015)

Towards "biophysical psychiatry": a modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability
por: Mäki-Marttunen, Tuomo, et al.
Publicado: (2015)

Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis
por: Datta, Harish K., et al.
Publicado: (2022)

In silico discovery of blood cell macromolecular associations
por: Gautvik, Kaare M., et al.
Publicado: (2022)

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults
por: Gautvik, Kaare M., et al.
Publicado: (2022)

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies
por: Thompson, Wesley K., et al.
Publicado: (2015)

Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data
por: Polushina, Tatiana, et al.
Publicado: (2017)

Large-scale genomics unveil polygenic architecture of human cortical surface area
por: Chen, Chi-Hua, et al.
Publicado: (2015)

Genetic loci shared between major depression and intelligence with mixed directions of effect
por: Bahrami, Shahram, et al.
Publicado: (2021)

Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD)
por: Karabegović, Irma, et al.
Publicado: (2017)

Identification of genetic loci shared between schizophrenia and the Big Five personality traits
por: Smeland, Olav B., et al.
Publicado: (2017)

Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
por: Desikan, Rahul S, et al.
Publicado: (2013)

Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
por: Witoelar, Aree, et al.
Publicado: (2018)

Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure
por: Chen, Chi-Hua, et al.
Publicado: (2017)

Rates of Decline in Alzheimer Disease Decrease with Age
por: Holland, Dominic, et al.
Publicado: (2012)

Enrichment and Stratification for Predementia Alzheimer Disease Clinical Trials
por: Holland, Dominic, et al.
Publicado: (2012)

Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease
por: Kauppi, Karolina, et al.
Publicado: (2018)

Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR
por: Shadrin, Alexey A, et al.
Publicado: (2020)

Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders
por: Haram, Marit, et al.
Publicado: (2016)

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
por: Frei, Oleksandr, et al.
Publicado: (2019)

Shared genetic loci between depression and cardiometabolic traits
por: Torgersen, Kristin, et al.
Publicado: (2022)

Altered Brain Activation during Emotional Face Processing in Relation to Both Diagnosis and Polygenic Risk of Bipolar Disorder
por: Tesli, Martin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e4telgk6rrit2ht9aj8t1lj44c