Basal Cell Carcinoma in Gorlin’s Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?

Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma...

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Detalles Bibliográficos
Autores principales: Gache, Yannick, Brellier, Florence, Rouanet, Sophie, Al-Qaraghuli, Sahar, Goncalves-Maia, Maria, Burty-Valin, Elodie, Barnay, Stéphanie, Scarzello, Sabine, Ruat, Martial, Sevenet, Nicolas, Avril, Marie-Françoise, Magnaldo, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687848/
https://www.ncbi.nlm.nih.gov/pubmed/26694869
http://dx.doi.org/10.1371/journal.pone.0145369

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