TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis

In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy. In the liver, TAK1-mediated autophagy plays a role in preventing excessive lipid...

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Autor principal: Seki, Ekihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687902/
https://www.ncbi.nlm.nih.gov/pubmed/26709386
http://dx.doi.org/10.4161/23723548.2014.968507
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author Seki, Ekihiro
author_facet Seki, Ekihiro
author_sort Seki, Ekihiro
collection PubMed
description In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy. In the liver, TAK1-mediated autophagy plays a role in preventing excessive lipid accumulation induced by starvation and fat overload. TAK1-mediated autophagy and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) prevent liver fibrosis and tumor development.
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spelling pubmed-46879022015-12-31 TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis Seki, Ekihiro Mol Cell Oncol Author's View In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy. In the liver, TAK1-mediated autophagy plays a role in preventing excessive lipid accumulation induced by starvation and fat overload. TAK1-mediated autophagy and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) prevent liver fibrosis and tumor development. Taylor & Francis 2014-12-31 /pmc/articles/PMC4687902/ /pubmed/26709386 http://dx.doi.org/10.4161/23723548.2014.968507 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Seki, Ekihiro
TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
title TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
title_full TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
title_fullStr TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
title_full_unstemmed TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
title_short TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis
title_sort tak1-dependent autophagy: a suppressor of fatty liver disease and hepatic oncogenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687902/
https://www.ncbi.nlm.nih.gov/pubmed/26709386
http://dx.doi.org/10.4161/23723548.2014.968507
work_keys_str_mv AT sekiekihiro tak1dependentautophagyasuppressoroffattyliverdiseaseandhepaticoncogenesis

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