Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough

Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3’ end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA binding sites,...

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Detalles Bibliográficos
Autores principales: Holmes, Rebecca K., Tuck, Alex C., Zhu, Chenchen, Dunn-Davies, Hywel R., Kudla, Grzegorz, Clauder-Munster, Sandra, Granneman, Sander, Steinmetz, Lars M., Guthrie, Christine, Tollervey, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687934/
https://www.ncbi.nlm.nih.gov/pubmed/26694144
http://dx.doi.org/10.1371/journal.pgen.1005735

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