LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, but not OTULIN, are recruited to the TNFR1- and NOD2...

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Detalles Bibliográficos
Autores principales: Draber, Peter, Kupka, Sebastian, Reichert, Matthias, Draberova, Helena, Lafont, Elodie, de Miguel, Diego, Spilgies, Lisanne, Surinova, Silvia, Taraborrelli, Lucia, Hartwig, Torsten, Rieser, Eva, Martino, Luigi, Rittinger, Katrin, Walczak, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688036/
https://www.ncbi.nlm.nih.gov/pubmed/26670046
http://dx.doi.org/10.1016/j.celrep.2015.11.009

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