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New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences

Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long...

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Autor principal: Peñagarikano, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688330/
https://www.ncbi.nlm.nih.gov/pubmed/26713078
http://dx.doi.org/10.5607/en.2015.24.4.301
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author Peñagarikano, Olga
author_facet Peñagarikano, Olga
author_sort Peñagarikano, Olga
collection PubMed
description Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long impeded the advancement of the development of successful pharmacotherapies. However, in the recent years, the integration of findings of multiple levels of research, from human genetics to mouse models, have made considerable progress towards the understanding of ASD pathophysiology, allowing the development of more effective targeted drug therapies. The present review discusses the current state of pharmacological research in ASD based on the emerging common pathophysiology signature.
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spelling pubmed-46883302015-12-28 New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences Peñagarikano, Olga Exp Neurobiol Review Article: Autism Spectrum Disorders Autism spectrum disorder (ASD) is characterized by impairment in two behavioral domains: social interaction/communication together with the presence of stereotyped behaviors and restricted interests. The heterogeneity in the phenotype among patients and the complex etiology of the disorder have long impeded the advancement of the development of successful pharmacotherapies. However, in the recent years, the integration of findings of multiple levels of research, from human genetics to mouse models, have made considerable progress towards the understanding of ASD pathophysiology, allowing the development of more effective targeted drug therapies. The present review discusses the current state of pharmacological research in ASD based on the emerging common pathophysiology signature. The Korean Society for Brain and Neural Science 2015-12 2015-12-16 /pmc/articles/PMC4688330/ /pubmed/26713078 http://dx.doi.org/10.5607/en.2015.24.4.301 Text en Copyright © Experimental Neurobiology 2015. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article: Autism Spectrum Disorders
Peñagarikano, Olga
New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences
title New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences
title_full New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences
title_fullStr New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences
title_full_unstemmed New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences
title_short New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences
title_sort new therapeutic options for autism spectrum disorder: experimental evidences
topic Review Article: Autism Spectrum Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688330/
https://www.ncbi.nlm.nih.gov/pubmed/26713078
http://dx.doi.org/10.5607/en.2015.24.4.301
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