Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

BACKGROUND: The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with tre...

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Detalles Bibliográficos
Autores principales: Duru, Valentine, Khim, Nimol, Leang, Rithea, Kim, Saorin, Domergue, Anais, Kloeung, Nimol, Ke, Sopheakvatey, Chy, Sophy, Eam, Rotha, Khean, Chanra, Loch, Kaknika, Ken, Malen, Lek, Dysoley, Beghain, Johann, Ariey, Frédéric, Guerin, Philippe J., Huy, Rekol, Mercereau-Puijalon, Odile, Witkowski, Benoit, Menard, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688949/
https://www.ncbi.nlm.nih.gov/pubmed/26695060
http://dx.doi.org/10.1186/s12916-015-0539-5

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