Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases

Epigenetic deregulation is a common feature in the pathogenesis of Epstein–Barr Virus (EBV)-related lymphomas and carcinomas. Previous studies have demonstrated a strong association between EBV latency in B-cells and epigenetic silencing of the tumor suppressor gene BIM. This study aimed to the cons...

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Autores principales: Rouka, Erasmia, Kyriakou, Despoina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688984/
https://www.ncbi.nlm.nih.gov/pubmed/26702402
http://dx.doi.org/10.1186/s40709-015-0037-0
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author Rouka, Erasmia
Kyriakou, Despoina
author_facet Rouka, Erasmia
Kyriakou, Despoina
author_sort Rouka, Erasmia
collection PubMed
description Epigenetic deregulation is a common feature in the pathogenesis of Epstein–Barr Virus (EBV)-related lymphomas and carcinomas. Previous studies have demonstrated a strong association between EBV latency in B-cells and epigenetic silencing of the tumor suppressor gene BIM. This study aimed to the construction and functional analysis of the BIM interactome in order to identify novel host genes that may be targeted by EBV. Fifty-nine unique interactors were found to compose the BIM gene network. Ontological analysis at the pathway level highlighted infectious diseases along with neuropathologies. These results underline the possible interplay between the BIM interactome and EBV-associated disorders.
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spelling pubmed-46889842015-12-24 Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases Rouka, Erasmia Kyriakou, Despoina J Biol Res (Thessalon) Letter to the Editor Epigenetic deregulation is a common feature in the pathogenesis of Epstein–Barr Virus (EBV)-related lymphomas and carcinomas. Previous studies have demonstrated a strong association between EBV latency in B-cells and epigenetic silencing of the tumor suppressor gene BIM. This study aimed to the construction and functional analysis of the BIM interactome in order to identify novel host genes that may be targeted by EBV. Fifty-nine unique interactors were found to compose the BIM gene network. Ontological analysis at the pathway level highlighted infectious diseases along with neuropathologies. These results underline the possible interplay between the BIM interactome and EBV-associated disorders. BioMed Central 2015-12-23 /pmc/articles/PMC4688984/ /pubmed/26702402 http://dx.doi.org/10.1186/s40709-015-0037-0 Text en © Rouka and Kyriakou. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Rouka, Erasmia
Kyriakou, Despoina
Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases
title Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases
title_full Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases
title_fullStr Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases
title_full_unstemmed Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases
title_short Identification and functional analysis of the BIM interactome; new clues on its possible involvement in Epstein–Barr Virus-associated diseases
title_sort identification and functional analysis of the bim interactome; new clues on its possible involvement in epstein–barr virus-associated diseases
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688984/
https://www.ncbi.nlm.nih.gov/pubmed/26702402
http://dx.doi.org/10.1186/s40709-015-0037-0
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