Cargando…
Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats
OBJECTIVES: Quercetin exhibits a wide range of biological functions. The present study aimed to investigate the possible beneficial effects of rosiglitazone, quercetin as well as their combination on metabolic and biochemical changes associated with the fructose-induced metabolic syndrome (MS). MATE...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689015/ https://www.ncbi.nlm.nih.gov/pubmed/26729953 http://dx.doi.org/10.4103/0253-7613.169577 |
_version_ | 1782406779047510016 |
---|---|
author | Abo-youssef, Amira M. |
author_facet | Abo-youssef, Amira M. |
author_sort | Abo-youssef, Amira M. |
collection | PubMed |
description | OBJECTIVES: Quercetin exhibits a wide range of biological functions. The present study aimed to investigate the possible beneficial effects of rosiglitazone, quercetin as well as their combination on metabolic and biochemical changes associated with the fructose-induced metabolic syndrome (MS). MATERIALS AND METHODS: Four groups of rats were fed on fructose-enriched diet for 14 weeks. One group served as fructose-enriched diet control, while the remaining groups were treated with rosiglitazone (4 mg/kg/day), quercetin (50 mg/kg/day), and their combination during the last 4 weeks. A fifth group was fed on normal laboratory diet. At the end of the experiment, blood samples were withdrawn for the estimation of markers of MS. RESULTS: Rosiglitazone or quercetin attenuated the biochemical and metabolic changes associated with MS. The combination of rosiglitazone and quercetin nearly normalized these changes. CONCLUSION: Quercetin, as well as its combination with rosiglitazone, showed beneficial protective effects against metabolic and biochemical changes associated with MS. |
format | Online Article Text |
id | pubmed-4689015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46890152016-01-04 Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats Abo-youssef, Amira M. Indian J Pharmacol Research Article OBJECTIVES: Quercetin exhibits a wide range of biological functions. The present study aimed to investigate the possible beneficial effects of rosiglitazone, quercetin as well as their combination on metabolic and biochemical changes associated with the fructose-induced metabolic syndrome (MS). MATERIALS AND METHODS: Four groups of rats were fed on fructose-enriched diet for 14 weeks. One group served as fructose-enriched diet control, while the remaining groups were treated with rosiglitazone (4 mg/kg/day), quercetin (50 mg/kg/day), and their combination during the last 4 weeks. A fifth group was fed on normal laboratory diet. At the end of the experiment, blood samples were withdrawn for the estimation of markers of MS. RESULTS: Rosiglitazone or quercetin attenuated the biochemical and metabolic changes associated with MS. The combination of rosiglitazone and quercetin nearly normalized these changes. CONCLUSION: Quercetin, as well as its combination with rosiglitazone, showed beneficial protective effects against metabolic and biochemical changes associated with MS. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4689015/ /pubmed/26729953 http://dx.doi.org/10.4103/0253-7613.169577 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Abo-youssef, Amira M. Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
title | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
title_full | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
title_fullStr | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
title_full_unstemmed | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
title_short | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
title_sort | protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689015/ https://www.ncbi.nlm.nih.gov/pubmed/26729953 http://dx.doi.org/10.4103/0253-7613.169577 |
work_keys_str_mv | AT aboyoussefamiram protectiveeffectofrosiglitazonequercetinandtheircombinationonfructoseinducedmetabolicsyndromeinrats |