Cargando…

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current I(f): Novel electrophysiological insights and therapeutic potential

BACKGROUND: Bradycardic agents are of interest for the treatment of ischemic heart disease and heart failure, as heart rate is an important determinant of myocardial oxygen consumption. OBJECTIVES: The purpose of this study was to investigate the propensity of hydroxychloroquine (HCQ) to cause brady...

Descripción completa

Detalles Bibliográficos
Autores principales:	Capel, Rebecca A., Herring, Neil, Kalla, Manish, Yavari, Arash, Mirams, Gary R., Douglas, Gillian, Bub, Gil, Channon, Keith, Paterson, David J., Terrar, Derek A., Burton, Rebecca-Ann B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689153/ https://www.ncbi.nlm.nih.gov/pubmed/26025323 http://dx.doi.org/10.1016/j.hrthm.2015.05.027

Ejemplares similares

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine
por: Whittaker, Dominic G., et al.
Publicado: (2021)

Cytosolic calcium ions exert a major influence on the firing rate and maintenance of pacemaker activity in guinea-pig sinus node
por: Capel, Rebecca A., et al.
Publicado: (2015)

The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat
por: Capel, Rebecca A., et al.
Publicado: (2015)

Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide
por: Kalla, Manish, et al.
Publicado: (2016)

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart
por: Aston, Daniel, et al.
Publicado: (2017)

Cardiac sympatho-vagal balance and ventricular arrhythmia()
por: Kalla, Manish, et al.
Publicado: (2016)

COSMAS: a lightweight toolbox for cardiac optical mapping analysis
por: Tomek, Jakub, et al.
Publicado: (2021)

Emerging Evidence for cAMP-calcium Cross Talk in Heart Atrial Nanodomains Where IP(3)-Evoked Calcium Release Stimulates Adenylyl Cyclases
por: Burton, Rebecca-Ann B., et al.
Publicado: (2021)

The Cardiac Electrophysiology Web Lab
por: Cooper, Jonathan, et al.
Publicado: (2016)

IP(3)-mediated Ca(2+) release regulates atrial Ca(2+) transients and pacemaker function by stimulation of adenylyl cyclases
por: Capel, Rebecca A., et al.
Publicado: (2021)

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP(3)-evoked changes in sino-atrial node beat rate
por: Bose, Samuel J., et al.
Publicado: (2022)

Cellular cardiac electrophysiology modeling with Chaste and CellML
por: Cooper, Jonathan, et al.
Publicado: (2015)

Calibration of ionic and cellular cardiac electrophysiology models
por: Whittaker, Dominic G., et al.
Publicado: (2020)

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing
por: Mirams, Gary R, et al.
Publicado: (2012)

Cardiac electrophysiological imaging systems scalable for high-throughput drug testing
por: Lee, Peter, et al.
Publicado: (2012)

β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and Computational Investigation of Arrhythmogenesis
por: Tomek, Jakub, et al.
Publicado: (2019)

Reproducible model development in the cardiac electrophysiology Web Lab
por: Daly, Aidan C., et al.
Publicado: (2018)

Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology
por: Bowler, Louise A., et al.
Publicado: (2018)

Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics
por: Burton, Rebecca-Ann B., et al.
Publicado: (2020)

The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade
por: Kalla, Manish, et al.
Publicado: (2020)

Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissue
por: Walmsley, John, et al.
Publicado: (2015)

Effects of hydroxychloroquine on atrial electrophysiology in in silico wild-type and PITX2(+/-) atrial cardiomyocytes
por: Song, Euijun
Publicado: (2023)

Timing mechanisms to control heart rhythm and initiate arrhythmias: roles for intracellular organelles, signalling pathways and subsarcolemmal Ca(2+)
por: Terrar, Derek A.
Publicado: (2023)

Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt(+) Cells in Murine Heart
por: Wang, Yanwen, et al.
Publicado: (2017)

In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine
por: Ballet, Véronique, et al.
Publicado: (2022)

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
por: Capel, Rebecca A., et al.
Publicado: (2015)

Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca(2+) transients in murine heart
por: Wen, Q., et al.
Publicado: (2018)

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study
por: Walmsley, John, et al.
Publicado: (2013)

Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction
por: Herring, Neil, et al.
Publicado: (2019)

Synaptic Plasticity in Cardiac Innervation and Its Potential Role in Atrial Fibrillation
por: Ashton, Jesse L., et al.
Publicado: (2018)

Transportable hyperpolarized metabolites
por: Ji, Xiao, et al.
Publicado: (2017)

A hyperpolarized equilibrium for magnetic resonance
por: Hövener, Jan-Bernd, et al.
Publicado: (2013)

Considering discrepancy when calibrating a mechanistic electrophysiology model
por: Lei, Chon Lok, et al.
Publicado: (2020)

Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation
por: Stead, Rebecca, et al.
Publicado: (2016)

Strategies for the Hyperpolarization of Acetonitrile and Related Ligands by SABRE
por: Mewis, Ryan E., et al.
Publicado: (2014)

Movements near the Gate of a Hyperpolarization-activated Cation Channel
por: Rothberg, Brad S., et al.
Publicado: (2003)

Direct arterial injection of hyperpolarized (13)C‐labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution
por: Reynolds, Steven, et al.
Publicado: (2017)

Cardiovascular Applications of Hyperpolarized MRI
por: Tyler, Damian J.
Publicado: (2011)

Imaging Sequences for Hyperpolarized Solids
por: Lv, Xudong, et al.
Publicado: (2020)

Improving the Hyperpolarization of (31)P Nuclei by Synthetic Design
por: Burns, Michael J., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8okc0n02hbgbnpveci0t69r23p