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Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation

T cell (or transmembrane) immunoglobulin and mucin domain protein 3 (Tim-3) has attracted significant attention as a novel immune checkpoint receptor (ICR) on chronically stimulated, often dysfunctional, T cells. Antibodies to Tim-3 can enhance antiviral and antitumor immune responses. Tim-3 is also...

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Detalles Bibliográficos
Autores principales:	Phong, Binh L., Avery, Lyndsay, Sumpter, Tina L., Gorman, Jacob V., Watkins, Simon C., Colgan, John D., Kane, Lawrence P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689164/ https://www.ncbi.nlm.nih.gov/pubmed/26598760 http://dx.doi.org/10.1084/jem.20150388

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