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Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat

BACKGROUND: This study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. METHODS: Eighty male Wistar rats were divided into 8 groups of 10 e...

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Autores principales: Baharvand, Babak, Esmailidehaj, Mansour, Alihosaini, Jamileh, Bajoovand, Shirin, Esmailidehaj, Saeedeh, Hafizibarjin, Zeynab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689281/
https://www.ncbi.nlm.nih.gov/pubmed/26411972
http://dx.doi.org/10.7508/ibj.2016.01.006
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author Baharvand, Babak
Esmailidehaj, Mansour
Alihosaini, Jamileh
Bajoovand, Shirin
Esmailidehaj, Saeedeh
Hafizibarjin, Zeynab
author_facet Baharvand, Babak
Esmailidehaj, Mansour
Alihosaini, Jamileh
Bajoovand, Shirin
Esmailidehaj, Saeedeh
Hafizibarjin, Zeynab
author_sort Baharvand, Babak
collection PubMed
description BACKGROUND: This study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. METHODS: Eighty male Wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylactic and treatment control groups, groups 2 and 6 as the prophylactic and treatment groups with lidocaine (10 mg/kg), groups 3 and 4 as the prophylactic groups with 10 and 50 mg/kg oleuropein (i.v.), and groups 7 and 8 as the treatment groups with 10 and 50 mg/kg oleuropein (i.v.), respectively. Reperfusion injury was induced by 5-min regional ischemia and 15-min reperfusion of left anterior descending coronary artery. Heart rate, blood pressure, and electrocardiogram were monitored throughout the procedure. RESULTS: blood pressure was significantly decreased by infusion of 50 mg/kg oleuropein in groups 4 and 8, but unlike the lidocaine as a standard anti-arrhythmic drug in groups 2 and 5 had not significant effect on heart rate. The onset of arrhythmia in groups received oleuropein (groups 3, 4, 7, and 8) was significantly delayed. The mortality rate due to irreversible ventricular fibrillation was also significantly reduced in groups 3, 4, 7, and 8. The effect of lidocaine in groups 2 and 5 was more potent than that in oleuropein group. CONCLUSION: These findings indicate that i.v. injection of oleuropein possibly through its antioxidant activity reduces the magnitude of reperfusion-induced arrhythmia.
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spelling pubmed-46892812016-01-01 Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat Baharvand, Babak Esmailidehaj, Mansour Alihosaini, Jamileh Bajoovand, Shirin Esmailidehaj, Saeedeh Hafizibarjin, Zeynab Iran Biomed J Full Length BACKGROUND: This study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. METHODS: Eighty male Wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylactic and treatment control groups, groups 2 and 6 as the prophylactic and treatment groups with lidocaine (10 mg/kg), groups 3 and 4 as the prophylactic groups with 10 and 50 mg/kg oleuropein (i.v.), and groups 7 and 8 as the treatment groups with 10 and 50 mg/kg oleuropein (i.v.), respectively. Reperfusion injury was induced by 5-min regional ischemia and 15-min reperfusion of left anterior descending coronary artery. Heart rate, blood pressure, and electrocardiogram were monitored throughout the procedure. RESULTS: blood pressure was significantly decreased by infusion of 50 mg/kg oleuropein in groups 4 and 8, but unlike the lidocaine as a standard anti-arrhythmic drug in groups 2 and 5 had not significant effect on heart rate. The onset of arrhythmia in groups received oleuropein (groups 3, 4, 7, and 8) was significantly delayed. The mortality rate due to irreversible ventricular fibrillation was also significantly reduced in groups 3, 4, 7, and 8. The effect of lidocaine in groups 2 and 5 was more potent than that in oleuropein group. CONCLUSION: These findings indicate that i.v. injection of oleuropein possibly through its antioxidant activity reduces the magnitude of reperfusion-induced arrhythmia. Pasteur Institute of Iran 2016-01 /pmc/articles/PMC4689281/ /pubmed/26411972 http://dx.doi.org/10.7508/ibj.2016.01.006 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Length
Baharvand, Babak
Esmailidehaj, Mansour
Alihosaini, Jamileh
Bajoovand, Shirin
Esmailidehaj, Saeedeh
Hafizibarjin, Zeynab
Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat
title Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat
title_full Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat
title_fullStr Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat
title_full_unstemmed Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat
title_short Prophylactic and Therapeutic Effects of Oleuropein on Reperfusion-Induced Arrhythmia in Anesthetized Rat
title_sort prophylactic and therapeutic effects of oleuropein on reperfusion-induced arrhythmia in anesthetized rat
topic Full Length
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689281/
https://www.ncbi.nlm.nih.gov/pubmed/26411972
http://dx.doi.org/10.7508/ibj.2016.01.006
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