A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities

To find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef. We identified the GPG-motif, located at the 121–137 region of HIV-1 NL4.3 Nef, as a novel protein signature strictly requi...

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Detalles Bibliográficos
Autores principales: Martínez-Bonet, Marta, Palladino, Claudia, Briz, Veronica, Rudolph, Jochen M., Fackler, Oliver T., Relloso, Miguel, Muñoz-Fernandez, Maria Angeles, Madrid, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689412/
https://www.ncbi.nlm.nih.gov/pubmed/26700863
http://dx.doi.org/10.1371/journal.pone.0145239

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