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Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases

Cfr and RlmN methyltransferases both modify adenine 2503 in 23S rRNA (Escherichia coli numbering). RlmN methylates position C2 of adenine while Cfr methylates position C8, and to a lesser extent C2, conferring antibiotic resistance to peptidyl transferase inhibitors. Cfr and RlmN show high sequence...

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Detalles Bibliográficos
Autores principales:	Ntokou, Eleni, Hansen, Lykke Haastrup, Kongsted, Jacob, Vester, Birte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689488/ https://www.ncbi.nlm.nih.gov/pubmed/26700482 http://dx.doi.org/10.1371/journal.pone.0145655

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