Identification and Functional Characterization of Glycosylation of Recombinant Human Platelet-Derived Growth Factor-BB in Pichia pastoris

Yeast Pichia pastoris is a widely used system for heterologous protein expression. However, post-translational modifications, especially glycosylation, usually impede pharmaceutical application of recombinant proteins because of unexpected alterations in protein structure and function. The aim of th...

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Detalles Bibliográficos
Autores principales: Dai, Mengmeng, Yu, Changming, Fang, Ting, Fu, Ling, Wang, Jing, Zhang, Jun, Ren, Jun, Xu, Junjie, Zhang, Xiaopeng, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689512/
https://www.ncbi.nlm.nih.gov/pubmed/26701617
http://dx.doi.org/10.1371/journal.pone.0145419

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