Cargando…

Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis

BACKGROUND: The AKT/mTORC1/S6K pathway is frequently overstimulated in breast cancer, constituting a promising therapeutic target. The benefit from mTOR inhibitors varies, likely as a consequence of tumour heterogeneity, and upregulation of several compensatory feed-back mechanisms. The mTORC1 downs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karlsson, Elin, Magić, Ivana, Bostner, Josefine, Dyrager, Christine, Lysholm, Fredrik, Hallbeck, Anna-Lotta, Stål, Olle, Lundström, Patrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689523/ https://www.ncbi.nlm.nih.gov/pubmed/26698305 http://dx.doi.org/10.1371/journal.pone.0145013

Ejemplares similares

The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials
por: Karlsson, Elin, et al.
Publicado: (2013)

Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit
por: Bostner, Josefine, et al.
Publicado: (2012)

Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer
por: Sridharan, Savitha, et al.
Publicado: (2020)

mTOR-S6K1 pathway mediates cytoophidium assembly
por: Sun, Zhe, et al.
Publicado: (2019)

IP6K2 predicts favorable clinical outcome of primary breast cancer
por: Sandström, Josefine, et al.
Publicado: (2021)

The Association of Aberrant Expression of FGF1 and mTOR-S6K1 in Colorectal Cancer
por: Duan, Tinghui, et al.
Publicado: (2021)

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
por: Heinonen, Henna, et al.
Publicado: (2008)

Interleukin-6 Secretion by Astrocytes Is Dynamically Regulated by PI3K-mTOR-Calcium Signaling
por: Codeluppi, Simone, et al.
Publicado: (2014)

Corrigendum: The Association of Aberrant Expression of FGF1 and mTOR-S6K1 in Colorectal Cancer
por: Duan, Tinghui, et al.
Publicado: (2021)

Chrysin Induces Apoptosis and Autophagy in Human Melanoma Cells via the mTOR/S6K Pathway
por: Lee, Jae-Han, et al.
Publicado: (2022)

Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation
por: Jeoung, Nam Ho, et al.
Publicado: (2021)

The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168
por: Xie, Xiaoduo, et al.
Publicado: (2018)

LGR6 promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway
por: Ke, Jing, et al.
Publicado: (2018)

Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention
por: Tang, Zhi-Ming, et al.
Publicado: (2017)

mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division
por: Bonucci, Martina, et al.
Publicado: (2020)

Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors
por: Melick, Chase H., et al.
Publicado: (2020)

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
por: Fan, Shengnuo, et al.
Publicado: (2015)

PI3K-mTOR-S6K Signaling Mediates Neuronal Viability via Collapsin Response Mediator Protein-2 Expression
por: Na, Eun J., et al.
Publicado: (2017)

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
por: Li, Jie, et al.
Publicado: (2019)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Targeting PI3K/mTOR Signaling in Cancer
por: Arcaro, Alexandre
Publicado: (2014)

Collapsin Response Mediator Protein-2 Ameliorates Sevoflurane-Mediated Neurocyte Injury by Targeting PI3K-mTOR-S6K Pathway
por: He, Jiaxuan, et al.
Publicado: (2018)

TGF-β1 promotes the osteoinduction of human osteoblasts via the PI3K/AKT/mTOR/S6K1 signalling pathway
por: Zhang, Zhaodong, et al.
Publicado: (2019)

AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
por: Leal, Pamela, et al.
Publicado: (2013)

Huaier Extract Induces Autophagic Cell Death by Inhibiting the mTOR/S6K Pathway in Breast Cancer Cells
por: Wang, Xiaolong, et al.
Publicado: (2015)

Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway
por: Ma, Xiaomin, et al.
Publicado: (2016)

The mTOR/p70S6K1 signaling pathway in renal fibrosis of children with immunoglobulin A nephropathy
por: Xu, Yuanyuan, et al.
Publicado: (2017)

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway
por: Jiang, Kehua, et al.
Publicado: (2018)

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling
por: Li, Minjing, et al.
Publicado: (2017)

MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients
por: Olson, Carl O., et al.
Publicado: (2018)

Dock7 regulates AKT and mTOR/S6K activity required for the transformed phenotypes and survival of cancer cells
por: Teran, Oriana Y., et al.
Publicado: (2023)

Oligomeric β-Amyloid Suppresses Hippocampal γ-Oscillations through Activation of the mTOR/S6K1 Pathway
por: Wang, Ya-Li, et al.
Publicado: (2023)

m(6)A RNA modification modulates PI3K/Akt/mTOR signal pathway in Gastrointestinal Cancer
por: Zhao, Qijie, et al.
Publicado: (2020)

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells
por: Zhong, Wenying, et al.
Publicado: (2020)

Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer
por: Bostner, Josefine, et al.
Publicado: (2017)

Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells
por: Park, Soo Jung, et al.
Publicado: (2019)

Targeting PI3K/Akt/mTOR Signaling in Cancer
por: Porta, Camillo, et al.
Publicado: (2014)

Multipoint targeting of the PI3K/mTOR pathway in mesothelioma
por: Zhou, S, et al.
Publicado: (2014)

PI3K/Akt/mTOR inhibitors in breast cancer
por: Lee, Joycelyn JX, et al.
Publicado: (2015)

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
por: Trinh, X B, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_64nojj7qphc0g2oou16d4e8inl