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Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia. Although mainly second generation (2G) CARs carrying CD28 or 4-1BB have been investigated in patients, preclinical studies suggest that third generation (3G) CARs with both CD28 and 4-1BB have enhanced capaci...

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Detalles Bibliográficos
Autores principales:	Karlsson, Hannah, Svensson, Emma, Gigg, Camilla, Jarvius, Malin, Olsson-Strömberg, Ulla, Savoldo, Barbara, Dotti, Gianpietro, Loskog, Angelica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689545/ https://www.ncbi.nlm.nih.gov/pubmed/26700307 http://dx.doi.org/10.1371/journal.pone.0144787

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