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Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma.
Neurolymphomatosis (NL) is a rare disease characterized by malignant lymphocytes infiltrating various structures of the nervous system. It typically manifests as a neuropathy involving the peripheral nerves, nerve roots, plexuses, or cranial nerves. It often presents as a complication of lymphoma, b...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689559/ https://www.ncbi.nlm.nih.gov/pubmed/26719822 http://dx.doi.org/10.7759/cureus.379 |
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author | Shaikh, Faiq Savells, Derek Awan, Omer Inayat, Faisal Chaudhry, Ammar Jerath, Nivedita Graham, Michael M |
author_facet | Shaikh, Faiq Savells, Derek Awan, Omer Inayat, Faisal Chaudhry, Ammar Jerath, Nivedita Graham, Michael M |
author_sort | Shaikh, Faiq |
collection | PubMed |
description | Neurolymphomatosis (NL) is a rare disease characterized by malignant lymphocytes infiltrating various structures of the nervous system. It typically manifests as a neuropathy involving the peripheral nerves, nerve roots, plexuses, or cranial nerves. It often presents as a complication of lymphoma, but it can be the presenting feature of recurrent lymphoma. It is essential to identify and initiate treatment early with chemotherapy and/or radiation therapy in all cases of nodal or visceral (including neural) involvement with lymphoma. There are various diagnostic tests that can be used for its detection, such as cerebrospinal spinal fluid (CSF) cytology, electromyography (EMG), magnetic resonance imaging (MRI), and positron-emission tomography/computed tomography (PET/CT). FDG-PET/CT is the standard of care in lymphoma staging, restaging, and therapy response assessment, but has an inherent limitation in the detection of disease involvement in the central nervous system. While that is mostly true for visual assessment, there are quantitative methods to measure variation in the metabolic activity in the brain, which in turn helps detect the occurrence of neurolymphomatosis. |
format | Online Article Text |
id | pubmed-4689559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-46895592015-12-30 Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. Shaikh, Faiq Savells, Derek Awan, Omer Inayat, Faisal Chaudhry, Ammar Jerath, Nivedita Graham, Michael M Cureus Radiology Neurolymphomatosis (NL) is a rare disease characterized by malignant lymphocytes infiltrating various structures of the nervous system. It typically manifests as a neuropathy involving the peripheral nerves, nerve roots, plexuses, or cranial nerves. It often presents as a complication of lymphoma, but it can be the presenting feature of recurrent lymphoma. It is essential to identify and initiate treatment early with chemotherapy and/or radiation therapy in all cases of nodal or visceral (including neural) involvement with lymphoma. There are various diagnostic tests that can be used for its detection, such as cerebrospinal spinal fluid (CSF) cytology, electromyography (EMG), magnetic resonance imaging (MRI), and positron-emission tomography/computed tomography (PET/CT). FDG-PET/CT is the standard of care in lymphoma staging, restaging, and therapy response assessment, but has an inherent limitation in the detection of disease involvement in the central nervous system. While that is mostly true for visual assessment, there are quantitative methods to measure variation in the metabolic activity in the brain, which in turn helps detect the occurrence of neurolymphomatosis. Cureus 2015-11-13 /pmc/articles/PMC4689559/ /pubmed/26719822 http://dx.doi.org/10.7759/cureus.379 Text en Copyright © 2015, Shaikh et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Radiology Shaikh, Faiq Savells, Derek Awan, Omer Inayat, Faisal Chaudhry, Ammar Jerath, Nivedita Graham, Michael M Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. |
title | Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. |
title_full | Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. |
title_fullStr | Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. |
title_full_unstemmed | Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. |
title_short | Quantitative Imaging Analysis of FDG PET/CT Imaging for Detection of Central Neurolymphomatosis in a Case of Recurrent Diffuse B-Cell Lymphoma. |
title_sort | quantitative imaging analysis of fdg pet/ct imaging for detection of central neurolymphomatosis in a case of recurrent diffuse b-cell lymphoma. |
topic | Radiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689559/ https://www.ncbi.nlm.nih.gov/pubmed/26719822 http://dx.doi.org/10.7759/cureus.379 |
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