Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome

SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILAC-based proteomic studies using an oxaborole analo...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Deuan C., Foth, Bernardo J., Urbaniak, Michael D., Patterson, Stephen, Ong, Han B., Berriman, Matthew, Fairlamb, Alan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689576/
https://www.ncbi.nlm.nih.gov/pubmed/26684831
http://dx.doi.org/10.1371/journal.pntd.0004299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689576/
https://www.ncbi.nlm.nih.gov/pubmed/26684831
http://dx.doi.org/10.1371/journal.pntd.0004299

Ejemplares similares