Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension

BACKGROUND: Pulmonary arterial hypertension (PAH) worsens clinical outcomes in former preterm infants with bronchopulmonary dysplasia (BPD). Oxidant stress disrupts alveolar and vascular development in models of BPD. Bleomycin causes oxidative stress and induces BPD and PAH in neonatal rats. Disrupt...

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Detalles Bibliográficos
Autores principales: Delaney, Cassidy, Wright, Rachel H., Tang, Jen-Ruey, Woods, Crystal, Villegas, Leah, Sherlock, Laurie, Savani, Rashmin C., Abman, Steven H., Nozik-Grayck, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689645/
https://www.ncbi.nlm.nih.gov/pubmed/26322414
http://dx.doi.org/10.1038/pr.2015.166

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