Cargando…
Age-Related Changes in Inter-Network Connectivity by Component Analysis
Healthy aging is associated with brain changes that reflect an alteration to a functional unit in response to the available resources and architecture. Even before the onset of noticeable cognitive decline, the neural scaffolds underlying cognitive function undergo considerable change. Prior studies...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689781/ https://www.ncbi.nlm.nih.gov/pubmed/26733864 http://dx.doi.org/10.3389/fnagi.2015.00237 |
_version_ | 1782406890530013184 |
---|---|
author | La, Christian Mossahebi, Pouria Nair, Veena A. Bendlin, Barbara B. Birn, Rasmus Meyerand, Mary E. Prabhakaran, Vivek |
author_facet | La, Christian Mossahebi, Pouria Nair, Veena A. Bendlin, Barbara B. Birn, Rasmus Meyerand, Mary E. Prabhakaran, Vivek |
author_sort | La, Christian |
collection | PubMed |
description | Healthy aging is associated with brain changes that reflect an alteration to a functional unit in response to the available resources and architecture. Even before the onset of noticeable cognitive decline, the neural scaffolds underlying cognitive function undergo considerable change. Prior studies have suggested a disruption of the connectivity pattern within the “default-mode” network (DMN), and more specifically a disruption of the anterio-posterior connectivity. In this study, we explored the effects of aging on within-network connectivity of three DMN subnetworks: a posterior DMN (pDMN), an anterior DMN (aDMN), and a ventral DMN (vDMN); as well as between-network connectivity during resting-state. Using groupICA on 43 young and 43 older healthy adults, we showed a reduction of network co-activation in two of the DMN subnetworks (pDMN and aDMN) and demonstrated a difference in between-component connectivity levels. The older group exhibited more numerous high-correlation pairs (Pearson's rho > 0.3, Number of comp-pairs = 46) in comparison to the young group (Number of comp-pairs = 34), suggesting a more connected/less segregated cortical system. Moreover, three component-pairs exhibited statistically significant differences between the two populations. Visual areas V2–V1 and V2–V4 were more correlated in the older adults, while aDMN–pDMN correlation decreased with aging. The increase in the number of high-correlation component-pairs and the elevated correlation in the visual areas are consistent with the prior hypothesis that aging is associated with a reduction of functional segregation. However, the aDMN-pDMN dis-connectivity may be occurring under a different mechanism, a mechanism more related to a breakdown of structural integrity along the anterio-posterior axis. |
format | Online Article Text |
id | pubmed-4689781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46897812016-01-05 Age-Related Changes in Inter-Network Connectivity by Component Analysis La, Christian Mossahebi, Pouria Nair, Veena A. Bendlin, Barbara B. Birn, Rasmus Meyerand, Mary E. Prabhakaran, Vivek Front Aging Neurosci Neuroscience Healthy aging is associated with brain changes that reflect an alteration to a functional unit in response to the available resources and architecture. Even before the onset of noticeable cognitive decline, the neural scaffolds underlying cognitive function undergo considerable change. Prior studies have suggested a disruption of the connectivity pattern within the “default-mode” network (DMN), and more specifically a disruption of the anterio-posterior connectivity. In this study, we explored the effects of aging on within-network connectivity of three DMN subnetworks: a posterior DMN (pDMN), an anterior DMN (aDMN), and a ventral DMN (vDMN); as well as between-network connectivity during resting-state. Using groupICA on 43 young and 43 older healthy adults, we showed a reduction of network co-activation in two of the DMN subnetworks (pDMN and aDMN) and demonstrated a difference in between-component connectivity levels. The older group exhibited more numerous high-correlation pairs (Pearson's rho > 0.3, Number of comp-pairs = 46) in comparison to the young group (Number of comp-pairs = 34), suggesting a more connected/less segregated cortical system. Moreover, three component-pairs exhibited statistically significant differences between the two populations. Visual areas V2–V1 and V2–V4 were more correlated in the older adults, while aDMN–pDMN correlation decreased with aging. The increase in the number of high-correlation component-pairs and the elevated correlation in the visual areas are consistent with the prior hypothesis that aging is associated with a reduction of functional segregation. However, the aDMN-pDMN dis-connectivity may be occurring under a different mechanism, a mechanism more related to a breakdown of structural integrity along the anterio-posterior axis. Frontiers Media S.A. 2015-12-24 /pmc/articles/PMC4689781/ /pubmed/26733864 http://dx.doi.org/10.3389/fnagi.2015.00237 Text en Copyright © 2015 La, Mossahebi, Nair, Bendlin, Birn, Meyerand and Prabhakaran. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience La, Christian Mossahebi, Pouria Nair, Veena A. Bendlin, Barbara B. Birn, Rasmus Meyerand, Mary E. Prabhakaran, Vivek Age-Related Changes in Inter-Network Connectivity by Component Analysis |
title | Age-Related Changes in Inter-Network Connectivity by Component Analysis |
title_full | Age-Related Changes in Inter-Network Connectivity by Component Analysis |
title_fullStr | Age-Related Changes in Inter-Network Connectivity by Component Analysis |
title_full_unstemmed | Age-Related Changes in Inter-Network Connectivity by Component Analysis |
title_short | Age-Related Changes in Inter-Network Connectivity by Component Analysis |
title_sort | age-related changes in inter-network connectivity by component analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689781/ https://www.ncbi.nlm.nih.gov/pubmed/26733864 http://dx.doi.org/10.3389/fnagi.2015.00237 |
work_keys_str_mv | AT lachristian agerelatedchangesininternetworkconnectivitybycomponentanalysis AT mossahebipouria agerelatedchangesininternetworkconnectivitybycomponentanalysis AT nairveenaa agerelatedchangesininternetworkconnectivitybycomponentanalysis AT bendlinbarbarab agerelatedchangesininternetworkconnectivitybycomponentanalysis AT birnrasmus agerelatedchangesininternetworkconnectivitybycomponentanalysis AT meyerandmarye agerelatedchangesininternetworkconnectivitybycomponentanalysis AT prabhakaranvivek agerelatedchangesininternetworkconnectivitybycomponentanalysis |