Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway

Bufalin, a digoxin-like active component of the traditional Chinese medicine Chan Su, exhibits potent antitumor activities in many human cancers. Bufalin induces mitochondria-dependent apoptosis in cancer cells, but the detailed molecular mechanisms are largely unknown. hTERT, the catalytic subunit...

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Detalles Bibliográficos
Autores principales: Tian, Xin, Dai, Shundong, Sun, Jing, Jiang, Shenyi, Sui, Chengguang, Meng, Fandong, Li, Yan, Fu, Liye, Jiang, Tao, Wang, Yang, Su, Jia, Jiang, Youhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689913/
https://www.ncbi.nlm.nih.gov/pubmed/26783410
http://dx.doi.org/10.1155/2015/546210

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