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Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes

Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammato...

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Autores principales: Stefanini, Ana Carolina B., da Cunha, Bianca Rodrigues, Henrique, Tiago, Tajara, Eloiza H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689925/
https://www.ncbi.nlm.nih.gov/pubmed/26783378
http://dx.doi.org/10.1155/2015/946572
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author Stefanini, Ana Carolina B.
da Cunha, Bianca Rodrigues
Henrique, Tiago
Tajara, Eloiza H.
author_facet Stefanini, Ana Carolina B.
da Cunha, Bianca Rodrigues
Henrique, Tiago
Tajara, Eloiza H.
author_sort Stefanini, Ana Carolina B.
collection PubMed
description Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the neoplastic phenotype through the regulation of several cellular processes, such as proliferation, survival, migration, and invasion. This family of proteases, which includes one of the most useful cancer biomarkers, kallikrein-related peptidase 3 or PSA, also has a protective effect against cancer promoting apoptosis or counteracting angiogenesis and cell proliferation. Therefore, they represent attractive therapeutic targets and may have important applications in clinical oncology. Despite being intensively studied, many gaps in our knowledge on several molecular aspects of KLK functions still exist. This review aims to summarize recent data on their involvement in different processes related to health and disease, in particular those directly or indirectly linked to the neoplastic process.
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spelling pubmed-46899252016-01-18 Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes Stefanini, Ana Carolina B. da Cunha, Bianca Rodrigues Henrique, Tiago Tajara, Eloiza H. Dis Markers Review Article Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the neoplastic phenotype through the regulation of several cellular processes, such as proliferation, survival, migration, and invasion. This family of proteases, which includes one of the most useful cancer biomarkers, kallikrein-related peptidase 3 or PSA, also has a protective effect against cancer promoting apoptosis or counteracting angiogenesis and cell proliferation. Therefore, they represent attractive therapeutic targets and may have important applications in clinical oncology. Despite being intensively studied, many gaps in our knowledge on several molecular aspects of KLK functions still exist. This review aims to summarize recent data on their involvement in different processes related to health and disease, in particular those directly or indirectly linked to the neoplastic process. Hindawi Publishing Corporation 2015 2015-12-09 /pmc/articles/PMC4689925/ /pubmed/26783378 http://dx.doi.org/10.1155/2015/946572 Text en Copyright © 2015 Ana Carolina B. Stefanini et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Stefanini, Ana Carolina B.
da Cunha, Bianca Rodrigues
Henrique, Tiago
Tajara, Eloiza H.
Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
title Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
title_full Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
title_fullStr Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
title_full_unstemmed Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
title_short Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
title_sort involvement of kallikrein-related peptidases in normal and pathologic processes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689925/
https://www.ncbi.nlm.nih.gov/pubmed/26783378
http://dx.doi.org/10.1155/2015/946572
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