Impact of Chromatin on HIV Replication

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target c...

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Detalles Bibliográficos
Autores principales: Agosto, Luis M., Gagne, Matthew, Henderson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690024/
https://www.ncbi.nlm.nih.gov/pubmed/26437430
http://dx.doi.org/10.3390/genes6040957
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author Agosto, Luis M.
Gagne, Matthew
Henderson, Andrew J.
author_facet Agosto, Luis M.
Gagne, Matthew
Henderson, Andrew J.
author_sort Agosto, Luis M.
collection PubMed
description Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.
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spelling pubmed-46900242015-12-30 Impact of Chromatin on HIV Replication Agosto, Luis M. Gagne, Matthew Henderson, Andrew J. Genes (Basel) Review Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed. MDPI 2015-09-30 /pmc/articles/PMC4690024/ /pubmed/26437430 http://dx.doi.org/10.3390/genes6040957 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Agosto, Luis M.
Gagne, Matthew
Henderson, Andrew J.
Impact of Chromatin on HIV Replication
title Impact of Chromatin on HIV Replication
title_full Impact of Chromatin on HIV Replication
title_fullStr Impact of Chromatin on HIV Replication
title_full_unstemmed Impact of Chromatin on HIV Replication
title_short Impact of Chromatin on HIV Replication
title_sort impact of chromatin on hiv replication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690024/
https://www.ncbi.nlm.nih.gov/pubmed/26437430
http://dx.doi.org/10.3390/genes6040957
work_keys_str_mv AT agostoluism impactofchromatinonhivreplication
AT gagnematthew impactofchromatinonhivreplication
AT hendersonandrewj impactofchromatinonhivreplication

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