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High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction

A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status...

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Autores principales: Pagliardini, Luca, Vigano’, Paola, Molgora, Michela, Persico, Paola, Salonia, Andrea, Vailati, Simona Helda, Paffoni, Alessio, Somigliana, Edgardo, Papaleo, Enrico, Candiani, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690068/
https://www.ncbi.nlm.nih.gov/pubmed/26633484
http://dx.doi.org/10.3390/nu7125516
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author Pagliardini, Luca
Vigano’, Paola
Molgora, Michela
Persico, Paola
Salonia, Andrea
Vailati, Simona Helda
Paffoni, Alessio
Somigliana, Edgardo
Papaleo, Enrico
Candiani, Massimo
author_facet Pagliardini, Luca
Vigano’, Paola
Molgora, Michela
Persico, Paola
Salonia, Andrea
Vailati, Simona Helda
Paffoni, Alessio
Somigliana, Edgardo
Papaleo, Enrico
Candiani, Massimo
author_sort Pagliardini, Luca
collection PubMed
description A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associated with BMI; conversely, 25(OH)D levels were positively associated with height and endometriosis history. Serum 25(OH)D levels are highly deficient in women seeking medical help for couple’s infertility. Levels are significantly associated with body composition, seasonal modifications and causes of infertility. Importantly, this deficiency status may last during pregnancy with more severe consequences.
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spelling pubmed-46900682015-12-30 High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction Pagliardini, Luca Vigano’, Paola Molgora, Michela Persico, Paola Salonia, Andrea Vailati, Simona Helda Paffoni, Alessio Somigliana, Edgardo Papaleo, Enrico Candiani, Massimo Nutrients Article A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associated with BMI; conversely, 25(OH)D levels were positively associated with height and endometriosis history. Serum 25(OH)D levels are highly deficient in women seeking medical help for couple’s infertility. Levels are significantly associated with body composition, seasonal modifications and causes of infertility. Importantly, this deficiency status may last during pregnancy with more severe consequences. MDPI 2015-12-02 /pmc/articles/PMC4690068/ /pubmed/26633484 http://dx.doi.org/10.3390/nu7125516 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pagliardini, Luca
Vigano’, Paola
Molgora, Michela
Persico, Paola
Salonia, Andrea
Vailati, Simona Helda
Paffoni, Alessio
Somigliana, Edgardo
Papaleo, Enrico
Candiani, Massimo
High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
title High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
title_full High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
title_fullStr High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
title_full_unstemmed High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
title_short High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
title_sort high prevalence of vitamin d deficiency in infertile women referring for assisted reproduction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690068/
https://www.ncbi.nlm.nih.gov/pubmed/26633484
http://dx.doi.org/10.3390/nu7125516
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