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High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction
A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690068/ https://www.ncbi.nlm.nih.gov/pubmed/26633484 http://dx.doi.org/10.3390/nu7125516 |
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author | Pagliardini, Luca Vigano’, Paola Molgora, Michela Persico, Paola Salonia, Andrea Vailati, Simona Helda Paffoni, Alessio Somigliana, Edgardo Papaleo, Enrico Candiani, Massimo |
author_facet | Pagliardini, Luca Vigano’, Paola Molgora, Michela Persico, Paola Salonia, Andrea Vailati, Simona Helda Paffoni, Alessio Somigliana, Edgardo Papaleo, Enrico Candiani, Massimo |
author_sort | Pagliardini, Luca |
collection | PubMed |
description | A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associated with BMI; conversely, 25(OH)D levels were positively associated with height and endometriosis history. Serum 25(OH)D levels are highly deficient in women seeking medical help for couple’s infertility. Levels are significantly associated with body composition, seasonal modifications and causes of infertility. Importantly, this deficiency status may last during pregnancy with more severe consequences. |
format | Online Article Text |
id | pubmed-4690068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46900682015-12-30 High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction Pagliardini, Luca Vigano’, Paola Molgora, Michela Persico, Paola Salonia, Andrea Vailati, Simona Helda Paffoni, Alessio Somigliana, Edgardo Papaleo, Enrico Candiani, Massimo Nutrients Article A comprehensive analysis of the vitamin D status of infertile women is the first step in understanding hypovitaminosis impact on reproductive potential. We sought to determine vitamin D profiles of women attending an infertility center and to investigate non-dietary determinants of vitamin D status in this population. In this cross-sectional analysis, a cohort of 1072 women (mean age ± standard deviation 36.3 ± 4.4 years) attending an academic infertility center was used to examine serum 25-hydroxy-vitamin D (25(OH)D) levels in relation to demographic characteristics, seasons and general health risk factors. Both unadjusted and adjusted levels of serum 25(OH)D were examined. Median 25(OH)D concentration was below 30 ng/mL for 89% of the entire year. Over the whole year, 6.5% of patients had 25(OH)D levels ≤10 ng/mL, 40.1% ≤20 ng/mL, and 77.4% ≤30 ng/mL. Global solar radiation was weakly correlated with 25(OH)D levels. At multivariable analysis, 25(OH)D levels were inversely associated with BMI; conversely, 25(OH)D levels were positively associated with height and endometriosis history. Serum 25(OH)D levels are highly deficient in women seeking medical help for couple’s infertility. Levels are significantly associated with body composition, seasonal modifications and causes of infertility. Importantly, this deficiency status may last during pregnancy with more severe consequences. MDPI 2015-12-02 /pmc/articles/PMC4690068/ /pubmed/26633484 http://dx.doi.org/10.3390/nu7125516 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pagliardini, Luca Vigano’, Paola Molgora, Michela Persico, Paola Salonia, Andrea Vailati, Simona Helda Paffoni, Alessio Somigliana, Edgardo Papaleo, Enrico Candiani, Massimo High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction |
title | High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction |
title_full | High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction |
title_fullStr | High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction |
title_full_unstemmed | High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction |
title_short | High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction |
title_sort | high prevalence of vitamin d deficiency in infertile women referring for assisted reproduction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690068/ https://www.ncbi.nlm.nih.gov/pubmed/26633484 http://dx.doi.org/10.3390/nu7125516 |
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