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Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children

Research findings are inconsistent about improvement of specific cardio-metabolic variables after lifestyle intervention in obese children. The aim of this trial was to evaluate the effect of a 1-year intervention, based on normocaloric diet and physical activity, on body mass index (BMI), blood lip...

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Autores principales: Verduci, Elvira, Lassandro, Carlotta, Giacchero, Roberta, Miniello, Vito Leonardo, Banderali, Giuseppe, Radaelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690072/
https://www.ncbi.nlm.nih.gov/pubmed/26633492
http://dx.doi.org/10.3390/nu7125520
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author Verduci, Elvira
Lassandro, Carlotta
Giacchero, Roberta
Miniello, Vito Leonardo
Banderali, Giuseppe
Radaelli, Giovanni
author_facet Verduci, Elvira
Lassandro, Carlotta
Giacchero, Roberta
Miniello, Vito Leonardo
Banderali, Giuseppe
Radaelli, Giovanni
author_sort Verduci, Elvira
collection PubMed
description Research findings are inconsistent about improvement of specific cardio-metabolic variables after lifestyle intervention in obese children. The aim of this trial was to evaluate the effect of a 1-year intervention, based on normocaloric diet and physical activity, on body mass index (BMI), blood lipid profile, glucose metabolism and metabolic syndrome. Eighty-five obese children aged ≥6 years were analyzed. The BMI z-score was calculated. Fasting blood samples were analyzed for lipids, insulin and glucose. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated and insulin resistance was defined as HOMA-IR >3.16. HOMA-β%, quantitative insulin sensitivity check index and triglyceride glucose index were calculated. The metabolic syndrome was defined in accordance with the International Diabetes Federation criteria. At the end of intervention children showed a reduction (mean (95% CI)) in BMI z-score (−0.58 (−0.66; −0.50)), triglycerides (−0.35 (−0.45; −0.25) mmol/L) and triglyceride glucose index (−0.29 (−0.37; −0.21)), and an increase in HDL cholesterol (0.06 (0.01; 0.11) mmol/L). Prevalence of insulin resistance declined from 51.8% to 36.5% and prevalence of metabolic syndrome from 17.1% to 4.9%. Nutritional-behavioral interventions can improve the blood lipid profile and insulin sensitivity in obese children, and possibly provide benefits in terms of metabolic syndrome.
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spelling pubmed-46900722015-12-30 Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children Verduci, Elvira Lassandro, Carlotta Giacchero, Roberta Miniello, Vito Leonardo Banderali, Giuseppe Radaelli, Giovanni Nutrients Article Research findings are inconsistent about improvement of specific cardio-metabolic variables after lifestyle intervention in obese children. The aim of this trial was to evaluate the effect of a 1-year intervention, based on normocaloric diet and physical activity, on body mass index (BMI), blood lipid profile, glucose metabolism and metabolic syndrome. Eighty-five obese children aged ≥6 years were analyzed. The BMI z-score was calculated. Fasting blood samples were analyzed for lipids, insulin and glucose. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated and insulin resistance was defined as HOMA-IR >3.16. HOMA-β%, quantitative insulin sensitivity check index and triglyceride glucose index were calculated. The metabolic syndrome was defined in accordance with the International Diabetes Federation criteria. At the end of intervention children showed a reduction (mean (95% CI)) in BMI z-score (−0.58 (−0.66; −0.50)), triglycerides (−0.35 (−0.45; −0.25) mmol/L) and triglyceride glucose index (−0.29 (−0.37; −0.21)), and an increase in HDL cholesterol (0.06 (0.01; 0.11) mmol/L). Prevalence of insulin resistance declined from 51.8% to 36.5% and prevalence of metabolic syndrome from 17.1% to 4.9%. Nutritional-behavioral interventions can improve the blood lipid profile and insulin sensitivity in obese children, and possibly provide benefits in terms of metabolic syndrome. MDPI 2015-12-03 /pmc/articles/PMC4690072/ /pubmed/26633492 http://dx.doi.org/10.3390/nu7125520 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Verduci, Elvira
Lassandro, Carlotta
Giacchero, Roberta
Miniello, Vito Leonardo
Banderali, Giuseppe
Radaelli, Giovanni
Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
title Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
title_full Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
title_fullStr Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
title_full_unstemmed Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
title_short Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
title_sort change in metabolic profile after 1-year nutritional-behavioral intervention in obese children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690072/
https://www.ncbi.nlm.nih.gov/pubmed/26633492
http://dx.doi.org/10.3390/nu7125520
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