Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)

The historical method for the detection of botulinum neurotoxin (BoNT) is represented by the mouse bioassay (MBA) measuring the animal survival rate. Since the endpoint of the MBA is the death of the mice due to paralysis of the respiratory muscle, an ex vivo animal replacement method, called mouse...

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Detalles Bibliográficos
Autores principales: Bigalke, Hans, Rummel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690105/
https://www.ncbi.nlm.nih.gov/pubmed/26610569
http://dx.doi.org/10.3390/toxins7124855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690105/
https://www.ncbi.nlm.nih.gov/pubmed/26610569
http://dx.doi.org/10.3390/toxins7124855

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