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The Industrial Age of Biocatalytic Transamination
During the last decade the use of ω-transaminases has been identified as a very powerful method for the preparation of optically pure amines from the corresponding ketones. Their immense potential for the preparation of chiral amines, together with their ease of use in combination with existing bioc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690199/ https://www.ncbi.nlm.nih.gov/pubmed/26726292 http://dx.doi.org/10.1002/ejoc.201500852 |
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author | Fuchs, Michael Farnberger, Judith E Kroutil, Wolfgang |
author_facet | Fuchs, Michael Farnberger, Judith E Kroutil, Wolfgang |
author_sort | Fuchs, Michael |
collection | PubMed |
description | During the last decade the use of ω-transaminases has been identified as a very powerful method for the preparation of optically pure amines from the corresponding ketones. Their immense potential for the preparation of chiral amines, together with their ease of use in combination with existing biocatalytic methods, have made these biocatalysts a competitor to any chemical methodology for (asymmetric) amination. An increasing number of examples, especially from industry, shows that this biocatalytic technology outmaneuvers existing chemical processes by its simple and flexible nature. In the last few years numerous publications and patents on synthetic routes, mainly to pharmaceuticals, involving ω-transaminases have been published. The review gives an overview of the application of ω-transaminases in organic synthesis with a focus on active pharmaceutical ingredients (APIs) and the developments during the last few years. |
format | Online Article Text |
id | pubmed-4690199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | WILEY-VCH Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-46901992015-12-31 The Industrial Age of Biocatalytic Transamination Fuchs, Michael Farnberger, Judith E Kroutil, Wolfgang European J Org Chem Microreview During the last decade the use of ω-transaminases has been identified as a very powerful method for the preparation of optically pure amines from the corresponding ketones. Their immense potential for the preparation of chiral amines, together with their ease of use in combination with existing biocatalytic methods, have made these biocatalysts a competitor to any chemical methodology for (asymmetric) amination. An increasing number of examples, especially from industry, shows that this biocatalytic technology outmaneuvers existing chemical processes by its simple and flexible nature. In the last few years numerous publications and patents on synthetic routes, mainly to pharmaceuticals, involving ω-transaminases have been published. The review gives an overview of the application of ω-transaminases in organic synthesis with a focus on active pharmaceutical ingredients (APIs) and the developments during the last few years. WILEY-VCH Verlag 2015-11 2015-09-23 /pmc/articles/PMC4690199/ /pubmed/26726292 http://dx.doi.org/10.1002/ejoc.201500852 Text en © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. https://creativecommons.org/licenses/by-nc-nd/4.0/ © 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Microreview Fuchs, Michael Farnberger, Judith E Kroutil, Wolfgang The Industrial Age of Biocatalytic Transamination |
title | The Industrial Age of Biocatalytic Transamination |
title_full | The Industrial Age of Biocatalytic Transamination |
title_fullStr | The Industrial Age of Biocatalytic Transamination |
title_full_unstemmed | The Industrial Age of Biocatalytic Transamination |
title_short | The Industrial Age of Biocatalytic Transamination |
title_sort | industrial age of biocatalytic transamination |
topic | Microreview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690199/ https://www.ncbi.nlm.nih.gov/pubmed/26726292 http://dx.doi.org/10.1002/ejoc.201500852 |
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