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Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis
Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by conducting a syst...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690422/ https://www.ncbi.nlm.nih.gov/pubmed/26697855 http://dx.doi.org/10.1186/s13018-015-0328-z |
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author | Zhang, Yunyuan Ding, Chunming Wang, Jing Sun, Guirong Cao, Yongxian Xu, Longqiang Zhou, Lan Chen, Xian |
author_facet | Zhang, Yunyuan Ding, Chunming Wang, Jing Sun, Guirong Cao, Yongxian Xu, Longqiang Zhou, Lan Chen, Xian |
author_sort | Zhang, Yunyuan |
collection | PubMed |
description | Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by conducting a systematic review and meta-analysis. A comprehensive search was conducted using PubMed (medline), Embase, ISI Web of Knowledge, Springer, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, Wanfang, Weipu, and China National Knowledge Internet (CNKI) databases from inception through May 26, 2015. All available articles written in English or Chinese that investigated the expression of CD44V6 and the prognosis of OS were included. The quantity of the studies was evaluated according to the critical review checklist of the Dutch Cochrane Centre proposed by MOOSE. Finally, a total of eight studies with 486 OS patients were involved and the results indicated that the positive expression of CD44V6 predicts neoplasm metastasis (RR = 1.76, 95 % CI 1.38–2.25, p < 0.00001), and poor survival in OS with the pooled HR of 1.53 (95 % CI 1.25–1.88, p < 0.0001). No significant heterogeneity was observed among all studies. In conclusion, the present meta-analysis and systematic review strongly suggest that CD44V6 over-expression is associated with overall survival rate and metastasis in OS, and may be used as a prognostic biomarker to guide the clinical therapy for OS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13018-015-0328-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4690422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46904222015-12-25 Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis Zhang, Yunyuan Ding, Chunming Wang, Jing Sun, Guirong Cao, Yongxian Xu, Longqiang Zhou, Lan Chen, Xian J Orthop Surg Res Review Numerous individual studies evaluating the relationship between CD44V6 over-expression and prognostic impact in patients with osteosarcoma (OS) have yielded in conclusive results. This meta-analysis aimed to determine the value of cell adhesion molecule CD44V6 in prognosis of OS by conducting a systematic review and meta-analysis. A comprehensive search was conducted using PubMed (medline), Embase, ISI Web of Knowledge, Springer, the Cochrane Library, Scopus, BioMed Central, ScienceDirect, Wanfang, Weipu, and China National Knowledge Internet (CNKI) databases from inception through May 26, 2015. All available articles written in English or Chinese that investigated the expression of CD44V6 and the prognosis of OS were included. The quantity of the studies was evaluated according to the critical review checklist of the Dutch Cochrane Centre proposed by MOOSE. Finally, a total of eight studies with 486 OS patients were involved and the results indicated that the positive expression of CD44V6 predicts neoplasm metastasis (RR = 1.76, 95 % CI 1.38–2.25, p < 0.00001), and poor survival in OS with the pooled HR of 1.53 (95 % CI 1.25–1.88, p < 0.0001). No significant heterogeneity was observed among all studies. In conclusion, the present meta-analysis and systematic review strongly suggest that CD44V6 over-expression is associated with overall survival rate and metastasis in OS, and may be used as a prognostic biomarker to guide the clinical therapy for OS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13018-015-0328-z) contains supplementary material, which is available to authorized users. BioMed Central 2015-12-23 /pmc/articles/PMC4690422/ /pubmed/26697855 http://dx.doi.org/10.1186/s13018-015-0328-z Text en © Zhang et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Zhang, Yunyuan Ding, Chunming Wang, Jing Sun, Guirong Cao, Yongxian Xu, Longqiang Zhou, Lan Chen, Xian Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis |
title | Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis |
title_full | Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis |
title_fullStr | Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis |
title_full_unstemmed | Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis |
title_short | Prognostic significance of CD44V6 expression in osteosarcoma: a meta-analysis |
title_sort | prognostic significance of cd44v6 expression in osteosarcoma: a meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690422/ https://www.ncbi.nlm.nih.gov/pubmed/26697855 http://dx.doi.org/10.1186/s13018-015-0328-z |
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