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Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis

PURPOSE: Previous studies have reported the association of an insertion/deletion (Ins/Del) polymorphism (rs3783553) in the 3′ untranslated region of interleukin-1A (IL-1A) with the risk of cancer, such as oral squamous cell carcinoma, nasopharyngeal carcinoma, and cervical carcinoma. However, the re...

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Autores principales: Ma, Ling, Zhou, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690651/
https://www.ncbi.nlm.nih.gov/pubmed/26719711
http://dx.doi.org/10.2147/OTT.S95887
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author Ma, Ling
Zhou, Ning
author_facet Ma, Ling
Zhou, Ning
author_sort Ma, Ling
collection PubMed
description PURPOSE: Previous studies have reported the association of an insertion/deletion (Ins/Del) polymorphism (rs3783553) in the 3′ untranslated region of interleukin-1A (IL-1A) with the risk of cancer, such as oral squamous cell carcinoma, nasopharyngeal carcinoma, and cervical carcinoma. However, the results are still inconsistent. The present meta-analysis aimed to clarify the association of IL-1A rs3783553 polymorphism with cancer risk. METHODS: All eligible studies were selected from PubMed, Web of Science, and Chinese National Knowledge Infrastructure up to September 2, 2015. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate cancer risk. RESULTS: A total of ten case–control studies with 4,514 cases and 6,689 controls were included this meta-analysis. We found that IL-1A rs3783553 polymorphism was significantly associated with cancer risk (Ins/Ins + Ins/Del vs Del/Del: OR =0.79, 95% CI =0.67–0.92; Ins/Ins vs Del/Del: OR =0.61, 95% CI =0.47–0.79; Ins/Ins vs Ins/Del + Del/Del: OR =0.67, 95% CI =0.55–0.83; Ins vs Del: OR =0.81, 95% CI =0.72–0.92). In the stratified analyses, significant effects were found among Asian populations (Ins/Ins + Ins/Del vs Del/Del: OR =0.81, 95% CI =0.69–0.95) and cervical carcinoma (Ins/Ins vs Del/Del: OR =0.51, 95% CI =0.34–0.76; Ins/Ins vs Ins/Del + Del/Del: OR =0.52, 95% CI =0.35–0.78). CONCLUSION: Our meta-analysis suggests that the IL-1A rs3783553 polymorphism contributes to susceptibility to cancer. However, well-designed studies with larger sample sizes are required to verify the results.
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spelling pubmed-46906512015-12-30 Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis Ma, Ling Zhou, Ning Onco Targets Ther Original Research PURPOSE: Previous studies have reported the association of an insertion/deletion (Ins/Del) polymorphism (rs3783553) in the 3′ untranslated region of interleukin-1A (IL-1A) with the risk of cancer, such as oral squamous cell carcinoma, nasopharyngeal carcinoma, and cervical carcinoma. However, the results are still inconsistent. The present meta-analysis aimed to clarify the association of IL-1A rs3783553 polymorphism with cancer risk. METHODS: All eligible studies were selected from PubMed, Web of Science, and Chinese National Knowledge Infrastructure up to September 2, 2015. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate cancer risk. RESULTS: A total of ten case–control studies with 4,514 cases and 6,689 controls were included this meta-analysis. We found that IL-1A rs3783553 polymorphism was significantly associated with cancer risk (Ins/Ins + Ins/Del vs Del/Del: OR =0.79, 95% CI =0.67–0.92; Ins/Ins vs Del/Del: OR =0.61, 95% CI =0.47–0.79; Ins/Ins vs Ins/Del + Del/Del: OR =0.67, 95% CI =0.55–0.83; Ins vs Del: OR =0.81, 95% CI =0.72–0.92). In the stratified analyses, significant effects were found among Asian populations (Ins/Ins + Ins/Del vs Del/Del: OR =0.81, 95% CI =0.69–0.95) and cervical carcinoma (Ins/Ins vs Del/Del: OR =0.51, 95% CI =0.34–0.76; Ins/Ins vs Ins/Del + Del/Del: OR =0.52, 95% CI =0.35–0.78). CONCLUSION: Our meta-analysis suggests that the IL-1A rs3783553 polymorphism contributes to susceptibility to cancer. However, well-designed studies with larger sample sizes are required to verify the results. Dove Medical Press 2015-12-18 /pmc/articles/PMC4690651/ /pubmed/26719711 http://dx.doi.org/10.2147/OTT.S95887 Text en © 2016 Ma and Zhou. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ma, Ling
Zhou, Ning
Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis
title Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis
title_full Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis
title_fullStr Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis
title_full_unstemmed Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis
title_short Association between an insertion/deletion polymorphism in IL-1A gene and cancer risk: a meta-analysis
title_sort association between an insertion/deletion polymorphism in il-1a gene and cancer risk: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690651/
https://www.ncbi.nlm.nih.gov/pubmed/26719711
http://dx.doi.org/10.2147/OTT.S95887
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