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Chemical synthesis and enzymatic, stereoselective hydrolysis of a functionalized dihydropyrimidine for the synthesis of β-amino acids

A novel substrate, 6-(4-nitrophenyl)dihydropyrimidine-2,4(1H,3H)-dione (pNO(2)PheDU), was chemically synthesized and analytically verified for the potential biocatalytic synthesis of enantiopure β-amino acids. The hydantoinase (EC 3.5.2.2) from Arthrobacter crystallopoietes DSM20117 was chosen to pr...

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Detalles Bibliográficos
Autores principales:	Slomka, Christin, Zhong, Sabilla, Fellinger, Anna, Engel, Ulrike, Syldatk, Christoph, Bräse, Stefan, Rudat, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690820/ https://www.ncbi.nlm.nih.gov/pubmed/26705241 http://dx.doi.org/10.1186/s13568-015-0174-8

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