Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication...

Descripción completa

Detalles Bibliográficos
Autores principales: Reynard, Olivier, Nguyen, Xuan-Nhi, Alazard-Dany, Nathalie, Barateau, Véronique, Cimarelli, Andrea, Volchkov, Viktor E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690858/
https://www.ncbi.nlm.nih.gov/pubmed/26633464
http://dx.doi.org/10.3390/v7122934
_version_ 1782407049163833344
author Reynard, Olivier
Nguyen, Xuan-Nhi
Alazard-Dany, Nathalie
Barateau, Véronique
Cimarelli, Andrea
Volchkov, Viktor E.
author_facet Reynard, Olivier
Nguyen, Xuan-Nhi
Alazard-Dany, Nathalie
Barateau, Véronique
Cimarelli, Andrea
Volchkov, Viktor E.
author_sort Reynard, Olivier
collection PubMed
description The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.
format Online
Article
Text
id pubmed-4690858
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-46908582016-01-04 Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication Reynard, Olivier Nguyen, Xuan-Nhi Alazard-Dany, Nathalie Barateau, Véronique Cimarelli, Andrea Volchkov, Viktor E. Viruses Brief Report The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV. MDPI 2015-12-02 /pmc/articles/PMC4690858/ /pubmed/26633464 http://dx.doi.org/10.3390/v7122934 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Reynard, Olivier
Nguyen, Xuan-Nhi
Alazard-Dany, Nathalie
Barateau, Véronique
Cimarelli, Andrea
Volchkov, Viktor E.
Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_full Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_fullStr Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_full_unstemmed Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_short Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_sort identification of a new ribonucleoside inhibitor of ebola virus replication
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690858/
https://www.ncbi.nlm.nih.gov/pubmed/26633464
http://dx.doi.org/10.3390/v7122934
work_keys_str_mv AT reynardolivier identificationofanewribonucleosideinhibitorofebolavirusreplication
AT nguyenxuannhi identificationofanewribonucleosideinhibitorofebolavirusreplication
AT alazarddanynathalie identificationofanewribonucleosideinhibitorofebolavirusreplication
AT barateauveronique identificationofanewribonucleosideinhibitorofebolavirusreplication
AT cimarelliandrea identificationofanewribonucleosideinhibitorofebolavirusreplication
AT volchkovviktore identificationofanewribonucleosideinhibitorofebolavirusreplication

Ejemplares similares