Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?

The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do...

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Detalles Bibliográficos
Autores principales: Turnbull, Samantha, West, Emma J., Scott, Karen J., Appleton, Elizabeth, Melcher, Alan, Ralph, Christy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690862/
https://www.ncbi.nlm.nih.gov/pubmed/26633468
http://dx.doi.org/10.3390/v7122938
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author Turnbull, Samantha
West, Emma J.
Scott, Karen J.
Appleton, Elizabeth
Melcher, Alan
Ralph, Christy
author_facet Turnbull, Samantha
West, Emma J.
Scott, Karen J.
Appleton, Elizabeth
Melcher, Alan
Ralph, Christy
author_sort Turnbull, Samantha
collection PubMed
description The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold.
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spelling pubmed-46908622016-01-04 Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? Turnbull, Samantha West, Emma J. Scott, Karen J. Appleton, Elizabeth Melcher, Alan Ralph, Christy Viruses Review The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold. MDPI 2015-12-02 /pmc/articles/PMC4690862/ /pubmed/26633468 http://dx.doi.org/10.3390/v7122938 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Turnbull, Samantha
West, Emma J.
Scott, Karen J.
Appleton, Elizabeth
Melcher, Alan
Ralph, Christy
Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
title Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
title_full Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
title_fullStr Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
title_full_unstemmed Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
title_short Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
title_sort evidence for oncolytic virotherapy: where have we got to and where are we going?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690862/
https://www.ncbi.nlm.nih.gov/pubmed/26633468
http://dx.doi.org/10.3390/v7122938
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