Cargando…
Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines
Enterovirus 71 (EV71) is a group of viruses that belongs to the Picornaviridae family, which also includes viruses such as polioviruses. EV71, together with coxsackieviruses, is widely known for its association with Hand Foot Mouth Disease (HFMD), which generally affects children age five and below....
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690872/ https://www.ncbi.nlm.nih.gov/pubmed/26670245 http://dx.doi.org/10.3390/v7122949 |
_version_ | 1782407052421758976 |
---|---|
author | Ng, Qingyong He, Fang Kwang, Jimmy |
author_facet | Ng, Qingyong He, Fang Kwang, Jimmy |
author_sort | Ng, Qingyong |
collection | PubMed |
description | Enterovirus 71 (EV71) is a group of viruses that belongs to the Picornaviridae family, which also includes viruses such as polioviruses. EV71, together with coxsackieviruses, is widely known for its association with Hand Foot Mouth Disease (HFMD), which generally affects children age five and below. Besides HFMD, EV71 can also trigger more severe and life-threatening neurological conditions such as encephalitis. Considering the lack of a vaccine and antiviral drug against EV71, together with the increasing spread of these viruses, the development of such drugs and vaccines becomes the top priority in protecting our younger generations. This article, hence, reviews some of the recent progress in the formulations of anti-therapeutics and vaccine generation for EV71, covering (i) inactivated vaccines; (ii) baculovirus-expressed vaccines against EV71; (iii) human intravenous immunoglobulin (IVIg) treatment; and (iv) the use of monoclonal antibody therapy as a prevention and treatment for EV71 infections. |
format | Online Article Text |
id | pubmed-4690872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46908722016-01-04 Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines Ng, Qingyong He, Fang Kwang, Jimmy Viruses Review Enterovirus 71 (EV71) is a group of viruses that belongs to the Picornaviridae family, which also includes viruses such as polioviruses. EV71, together with coxsackieviruses, is widely known for its association with Hand Foot Mouth Disease (HFMD), which generally affects children age five and below. Besides HFMD, EV71 can also trigger more severe and life-threatening neurological conditions such as encephalitis. Considering the lack of a vaccine and antiviral drug against EV71, together with the increasing spread of these viruses, the development of such drugs and vaccines becomes the top priority in protecting our younger generations. This article, hence, reviews some of the recent progress in the formulations of anti-therapeutics and vaccine generation for EV71, covering (i) inactivated vaccines; (ii) baculovirus-expressed vaccines against EV71; (iii) human intravenous immunoglobulin (IVIg) treatment; and (iv) the use of monoclonal antibody therapy as a prevention and treatment for EV71 infections. MDPI 2015-12-08 /pmc/articles/PMC4690872/ /pubmed/26670245 http://dx.doi.org/10.3390/v7122949 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ng, Qingyong He, Fang Kwang, Jimmy Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines |
title | Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines |
title_full | Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines |
title_fullStr | Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines |
title_full_unstemmed | Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines |
title_short | Recent Progress towards Novel EV71 Anti-Therapeutics and Vaccines |
title_sort | recent progress towards novel ev71 anti-therapeutics and vaccines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690872/ https://www.ncbi.nlm.nih.gov/pubmed/26670245 http://dx.doi.org/10.3390/v7122949 |
work_keys_str_mv | AT ngqingyong recentprogresstowardsnovelev71antitherapeuticsandvaccines AT hefang recentprogresstowardsnovelev71antitherapeuticsandvaccines AT kwangjimmy recentprogresstowardsnovelev71antitherapeuticsandvaccines |