Cargando…

Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China

Background: Exposure to artificial or natural endocrine disruptors, such as bisphenol A (BPA) and phytoestrogens has been demonstrated to have health effects, especially in children. Biomonitoring of BPA and phytoestrogens in human urine can be used to assess the intake levels of these compounds. Me...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mingyue, Duan, Zhenghua, Wu, Yinghong, Liu, Zhen, Li, Ke, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690900/
https://www.ncbi.nlm.nih.gov/pubmed/26633438
http://dx.doi.org/10.3390/ijerph121214964
_version_ 1782407058993184768
author Zhang, Mingyue
Duan, Zhenghua
Wu, Yinghong
Liu, Zhen
Li, Ke
Wang, Lei
author_facet Zhang, Mingyue
Duan, Zhenghua
Wu, Yinghong
Liu, Zhen
Li, Ke
Wang, Lei
author_sort Zhang, Mingyue
collection PubMed
description Background: Exposure to artificial or natural endocrine disruptors, such as bisphenol A (BPA) and phytoestrogens has been demonstrated to have health effects, especially in children. Biomonitoring of BPA and phytoestrogens in human urine can be used to assess the intake levels of these compounds. Methods: In this study, BPA and phytoestrogens in urine specimens (n = 256) collected from children in China were measured by liquid chromatography (LC)-tandem mass spectrometry (MS/MS). Results: BPA was detected in most specimens, with a geometric mean concentration of 1.58 ng/mL. For the first time, levels of urinary phytoestrogens in Chinese children were reported. Daidzein and enterolactone are the typical isoflavones and lignans compounds in urine, respectively. Conclusions: Relatively high levels of urinary BPA indicate an increasing risk of BPA exposure to Chinese children. Urinary concentrations of daidzein in Chinese children are higher when compared with those reported in the U.S. children, while concentrations of urinary enterolactone and enterodiols are significantly lower. This suggests a significant difference in phytoestrogen intake between the children from China and from the U.S.
format Online
Article
Text
id pubmed-4690900
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-46909002016-01-06 Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China Zhang, Mingyue Duan, Zhenghua Wu, Yinghong Liu, Zhen Li, Ke Wang, Lei Int J Environ Res Public Health Article Background: Exposure to artificial or natural endocrine disruptors, such as bisphenol A (BPA) and phytoestrogens has been demonstrated to have health effects, especially in children. Biomonitoring of BPA and phytoestrogens in human urine can be used to assess the intake levels of these compounds. Methods: In this study, BPA and phytoestrogens in urine specimens (n = 256) collected from children in China were measured by liquid chromatography (LC)-tandem mass spectrometry (MS/MS). Results: BPA was detected in most specimens, with a geometric mean concentration of 1.58 ng/mL. For the first time, levels of urinary phytoestrogens in Chinese children were reported. Daidzein and enterolactone are the typical isoflavones and lignans compounds in urine, respectively. Conclusions: Relatively high levels of urinary BPA indicate an increasing risk of BPA exposure to Chinese children. Urinary concentrations of daidzein in Chinese children are higher when compared with those reported in the U.S. children, while concentrations of urinary enterolactone and enterodiols are significantly lower. This suggests a significant difference in phytoestrogen intake between the children from China and from the U.S. MDPI 2015-11-30 2015-12 /pmc/articles/PMC4690900/ /pubmed/26633438 http://dx.doi.org/10.3390/ijerph121214964 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Mingyue
Duan, Zhenghua
Wu, Yinghong
Liu, Zhen
Li, Ke
Wang, Lei
Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China
title Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China
title_full Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China
title_fullStr Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China
title_full_unstemmed Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China
title_short Occurrence and Profiles of the Artificial Endocrine Disruptor Bisphenol A and Natural Endocrine Disruptor Phytoestrogens in Urine from Children in China
title_sort occurrence and profiles of the artificial endocrine disruptor bisphenol a and natural endocrine disruptor phytoestrogens in urine from children in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690900/
https://www.ncbi.nlm.nih.gov/pubmed/26633438
http://dx.doi.org/10.3390/ijerph121214964
work_keys_str_mv AT zhangmingyue occurrenceandprofilesoftheartificialendocrinedisruptorbisphenolaandnaturalendocrinedisruptorphytoestrogensinurinefromchildreninchina
AT duanzhenghua occurrenceandprofilesoftheartificialendocrinedisruptorbisphenolaandnaturalendocrinedisruptorphytoestrogensinurinefromchildreninchina
AT wuyinghong occurrenceandprofilesoftheartificialendocrinedisruptorbisphenolaandnaturalendocrinedisruptorphytoestrogensinurinefromchildreninchina
AT liuzhen occurrenceandprofilesoftheartificialendocrinedisruptorbisphenolaandnaturalendocrinedisruptorphytoestrogensinurinefromchildreninchina
AT like occurrenceandprofilesoftheartificialendocrinedisruptorbisphenolaandnaturalendocrinedisruptorphytoestrogensinurinefromchildreninchina
AT wanglei occurrenceandprofilesoftheartificialendocrinedisruptorbisphenolaandnaturalendocrinedisruptorphytoestrogensinurinefromchildreninchina