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Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates

Vibrio vulnificus is a halophilic bacterium of coastal environments known for sporadically causing severe foodborne or wound infections. Global warming is expected to lead to a rising occurrence of V. vulnificus and an increasing incidence of human infections in Northern Europe. So far, infections i...

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Autores principales: Bier, Nadja, Jäckel, Claudia, Dieckmann, Ralf, Brennholt, Nicole, Böer, Simone I., Strauch, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690967/
https://www.ncbi.nlm.nih.gov/pubmed/26694432
http://dx.doi.org/10.3390/ijerph121215031
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author Bier, Nadja
Jäckel, Claudia
Dieckmann, Ralf
Brennholt, Nicole
Böer, Simone I.
Strauch, Eckhard
author_facet Bier, Nadja
Jäckel, Claudia
Dieckmann, Ralf
Brennholt, Nicole
Böer, Simone I.
Strauch, Eckhard
author_sort Bier, Nadja
collection PubMed
description Vibrio vulnificus is a halophilic bacterium of coastal environments known for sporadically causing severe foodborne or wound infections. Global warming is expected to lead to a rising occurrence of V. vulnificus and an increasing incidence of human infections in Northern Europe. So far, infections in Germany were exclusively documented for the Baltic Sea coast, while no cases from the North Sea region have been reported. Regional variations in the prevalence of infections may be influenced by differences in the pathogenicity of V. vulnificus populations in both areas. This study aimed to compare the distribution of virulence-associated traits and genotypes among 101 V. vulnificus isolates from the Baltic Sea and North Sea in order to assess their pathogenicity potential. Furthermore, genetic relationships were examined by multilocus sequence typing (MLST). A high diversity of MLST sequences (74 sequence types) and differences regarding the presence of six potential pathogenicity markers were observed in the V. vulnificus populations of both areas. Strains with genotypes and markers associated with pathogenicity are not restricted to a particular geographic region. This indicates that lack of reported cases in the North Sea region is not caused by the absence of potentially pathogenic strains.
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spelling pubmed-46909672016-01-06 Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates Bier, Nadja Jäckel, Claudia Dieckmann, Ralf Brennholt, Nicole Böer, Simone I. Strauch, Eckhard Int J Environ Res Public Health Article Vibrio vulnificus is a halophilic bacterium of coastal environments known for sporadically causing severe foodborne or wound infections. Global warming is expected to lead to a rising occurrence of V. vulnificus and an increasing incidence of human infections in Northern Europe. So far, infections in Germany were exclusively documented for the Baltic Sea coast, while no cases from the North Sea region have been reported. Regional variations in the prevalence of infections may be influenced by differences in the pathogenicity of V. vulnificus populations in both areas. This study aimed to compare the distribution of virulence-associated traits and genotypes among 101 V. vulnificus isolates from the Baltic Sea and North Sea in order to assess their pathogenicity potential. Furthermore, genetic relationships were examined by multilocus sequence typing (MLST). A high diversity of MLST sequences (74 sequence types) and differences regarding the presence of six potential pathogenicity markers were observed in the V. vulnificus populations of both areas. Strains with genotypes and markers associated with pathogenicity are not restricted to a particular geographic region. This indicates that lack of reported cases in the North Sea region is not caused by the absence of potentially pathogenic strains. MDPI 2015-12-15 2015-12 /pmc/articles/PMC4690967/ /pubmed/26694432 http://dx.doi.org/10.3390/ijerph121215031 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bier, Nadja
Jäckel, Claudia
Dieckmann, Ralf
Brennholt, Nicole
Böer, Simone I.
Strauch, Eckhard
Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates
title Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates
title_full Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates
title_fullStr Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates
title_full_unstemmed Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates
title_short Virulence Profiles of Vibrio vulnificus in German Coastal Waters, a Comparison of North Sea and Baltic Sea Isolates
title_sort virulence profiles of vibrio vulnificus in german coastal waters, a comparison of north sea and baltic sea isolates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690967/
https://www.ncbi.nlm.nih.gov/pubmed/26694432
http://dx.doi.org/10.3390/ijerph121215031
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