Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information

[Image: see text] Toyocamycin nitrile hydratase (TNH) is a protein hexamer that catalyzes the hydration of toyocamycin to produce sangivamycin. The structure of hexameric TNH and the arrangement of subunits within the complex, however, have not been solved by NMR or X-ray crystallography. Native mas...

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Detalles Bibliográficos
Autores principales: Song, Yang, Nelp, Micah T., Bandarian, Vahe, Wysocki, Vicki H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690985/
https://www.ncbi.nlm.nih.gov/pubmed/26744735
http://dx.doi.org/10.1021/acscentsci.5b00251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690985/
https://www.ncbi.nlm.nih.gov/pubmed/26744735
http://dx.doi.org/10.1021/acscentsci.5b00251

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