Cargando…
One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon
Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron re...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691077/ https://www.ncbi.nlm.nih.gov/pubmed/26690427 http://dx.doi.org/10.3390/ijms161226130 |
_version_ | 1782407094494822400 |
---|---|
author | Szabó, László Tóth, Tünde Takács, Erzsébet Wojnárovits, László |
author_facet | Szabó, László Tóth, Tünde Takács, Erzsébet Wojnárovits, László |
author_sort | Szabó, László |
collection | PubMed |
description | Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron reduction mechanism of selected penicillin derivatives using pulse radiolysis techniques. Penicillins can accommodate the electron on each of their carbonyl carbon. Ketyl radicals are thus produced, which are reducing agents with possibility to interact with suitable biomolecules. A detailed mechanism of the reduction is reported. |
format | Online Article Text |
id | pubmed-4691077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46910772016-01-06 One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon Szabó, László Tóth, Tünde Takács, Erzsébet Wojnárovits, László Int J Mol Sci Communication Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron reduction mechanism of selected penicillin derivatives using pulse radiolysis techniques. Penicillins can accommodate the electron on each of their carbonyl carbon. Ketyl radicals are thus produced, which are reducing agents with possibility to interact with suitable biomolecules. A detailed mechanism of the reduction is reported. MDPI 2015-12-11 /pmc/articles/PMC4691077/ /pubmed/26690427 http://dx.doi.org/10.3390/ijms161226130 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Szabó, László Tóth, Tünde Takács, Erzsébet Wojnárovits, László One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon |
title | One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon |
title_full | One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon |
title_fullStr | One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon |
title_full_unstemmed | One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon |
title_short | One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon |
title_sort | one-electron reduction of penicillins in relation to the oxidative stress phenomenon |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691077/ https://www.ncbi.nlm.nih.gov/pubmed/26690427 http://dx.doi.org/10.3390/ijms161226130 |
work_keys_str_mv | AT szabolaszlo oneelectronreductionofpenicillinsinrelationtotheoxidativestressphenomenon AT tothtunde oneelectronreductionofpenicillinsinrelationtotheoxidativestressphenomenon AT takacserzsebet oneelectronreductionofpenicillinsinrelationtotheoxidativestressphenomenon AT wojnarovitslaszlo oneelectronreductionofpenicillinsinrelationtotheoxidativestressphenomenon |