Cargando…

Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma

A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrozza, Vincenzo, Carbone, Antonio, Bellissimo, Teresa, Porta, Natale, Palleschi, Giovanni, Pastore, Antonio Luigi, Di Carlo, Angelina, Della Rocca, Carlo, Fazi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691105/
https://www.ncbi.nlm.nih.gov/pubmed/26670229
http://dx.doi.org/10.3390/ijms161226160
_version_ 1782407100997042176
author Petrozza, Vincenzo
Carbone, Antonio
Bellissimo, Teresa
Porta, Natale
Palleschi, Giovanni
Pastore, Antonio Luigi
Di Carlo, Angelina
Della Rocca, Carlo
Fazi, Francesco
author_facet Petrozza, Vincenzo
Carbone, Antonio
Bellissimo, Teresa
Porta, Natale
Palleschi, Giovanni
Pastore, Antonio Luigi
Di Carlo, Angelina
Della Rocca, Carlo
Fazi, Francesco
author_sort Petrozza, Vincenzo
collection PubMed
description A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management.
format Online
Article
Text
id pubmed-4691105
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-46911052016-01-06 Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma Petrozza, Vincenzo Carbone, Antonio Bellissimo, Teresa Porta, Natale Palleschi, Giovanni Pastore, Antonio Luigi Di Carlo, Angelina Della Rocca, Carlo Fazi, Francesco Int J Mol Sci Brief Report A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management. MDPI 2015-12-08 /pmc/articles/PMC4691105/ /pubmed/26670229 http://dx.doi.org/10.3390/ijms161226160 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Petrozza, Vincenzo
Carbone, Antonio
Bellissimo, Teresa
Porta, Natale
Palleschi, Giovanni
Pastore, Antonio Luigi
Di Carlo, Angelina
Della Rocca, Carlo
Fazi, Francesco
Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
title Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
title_full Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
title_fullStr Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
title_full_unstemmed Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
title_short Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
title_sort oncogenic micrornas characterization in clear cell renal cell carcinoma
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691105/
https://www.ncbi.nlm.nih.gov/pubmed/26670229
http://dx.doi.org/10.3390/ijms161226160
work_keys_str_mv AT petrozzavincenzo oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT carboneantonio oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT bellissimoteresa oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT portanatale oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT palleschigiovanni oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT pastoreantonioluigi oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT dicarloangelina oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT dellaroccacarlo oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma
AT fazifrancesco oncogenicmicrornascharacterizationinclearcellrenalcellcarcinoma