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Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma
A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691105/ https://www.ncbi.nlm.nih.gov/pubmed/26670229 http://dx.doi.org/10.3390/ijms161226160 |
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author | Petrozza, Vincenzo Carbone, Antonio Bellissimo, Teresa Porta, Natale Palleschi, Giovanni Pastore, Antonio Luigi Di Carlo, Angelina Della Rocca, Carlo Fazi, Francesco |
author_facet | Petrozza, Vincenzo Carbone, Antonio Bellissimo, Teresa Porta, Natale Palleschi, Giovanni Pastore, Antonio Luigi Di Carlo, Angelina Della Rocca, Carlo Fazi, Francesco |
author_sort | Petrozza, Vincenzo |
collection | PubMed |
description | A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management. |
format | Online Article Text |
id | pubmed-4691105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46911052016-01-06 Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma Petrozza, Vincenzo Carbone, Antonio Bellissimo, Teresa Porta, Natale Palleschi, Giovanni Pastore, Antonio Luigi Di Carlo, Angelina Della Rocca, Carlo Fazi, Francesco Int J Mol Sci Brief Report A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management. MDPI 2015-12-08 /pmc/articles/PMC4691105/ /pubmed/26670229 http://dx.doi.org/10.3390/ijms161226160 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Petrozza, Vincenzo Carbone, Antonio Bellissimo, Teresa Porta, Natale Palleschi, Giovanni Pastore, Antonio Luigi Di Carlo, Angelina Della Rocca, Carlo Fazi, Francesco Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma |
title | Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma |
title_full | Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma |
title_fullStr | Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma |
title_full_unstemmed | Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma |
title_short | Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma |
title_sort | oncogenic micrornas characterization in clear cell renal cell carcinoma |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691105/ https://www.ncbi.nlm.nih.gov/pubmed/26670229 http://dx.doi.org/10.3390/ijms161226160 |
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