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IL-18 and Cutaneous Inflammatory Diseases
Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691115/ https://www.ncbi.nlm.nih.gov/pubmed/26690141 http://dx.doi.org/10.3390/ijms161226172 |
| _version_ | 1782407103315443712 |
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| author | Lee, Ji hyun Cho, Dae Ho Park, Hyun Jeong |
| author_facet | Lee, Ji hyun Cho, Dae Ho Park, Hyun Jeong |
| author_sort | Lee, Ji hyun |
| collection | PubMed |
| description | Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities. |
| format | Online Article Text |
| id | pubmed-4691115 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46911152016-01-06 IL-18 and Cutaneous Inflammatory Diseases Lee, Ji hyun Cho, Dae Ho Park, Hyun Jeong Int J Mol Sci Review Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities. MDPI 2015-12-09 /pmc/articles/PMC4691115/ /pubmed/26690141 http://dx.doi.org/10.3390/ijms161226172 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Lee, Ji hyun Cho, Dae Ho Park, Hyun Jeong IL-18 and Cutaneous Inflammatory Diseases |
| title | IL-18 and Cutaneous Inflammatory Diseases |
| title_full | IL-18 and Cutaneous Inflammatory Diseases |
| title_fullStr | IL-18 and Cutaneous Inflammatory Diseases |
| title_full_unstemmed | IL-18 and Cutaneous Inflammatory Diseases |
| title_short | IL-18 and Cutaneous Inflammatory Diseases |
| title_sort | il-18 and cutaneous inflammatory diseases |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691115/ https://www.ncbi.nlm.nih.gov/pubmed/26690141 http://dx.doi.org/10.3390/ijms161226172 |
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