DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids

Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence, genomic damage may accumulate in sperm and be transmitted to the zygote. Indirect, delayed DNA fragmentation and lesions asso...

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Detalles Bibliográficos
Autores principales: Ahmed, Emad A., Scherthan, Harry, de Rooij, Dirk G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691157/
https://www.ncbi.nlm.nih.gov/pubmed/26694360
http://dx.doi.org/10.3390/ijms161226214

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