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Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report

The aim of this study is to describe the results obtained after growth hormone (GH) treatment and neurorehabilitation in a young man that suffered a very grave traumatic brain injury (TBI) after a plane crash. Methods: Fifteen months after the accident, the patient was treated with GH, 1 mg/day, at...

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Autores principales: Devesa, Jesús, Díaz-Getino, Gustavo, Rey, Pablo, García-Cancela, José, Loures, Iria, Nogueiras, Sonia, Hurtado de Mendoza, Alba, Salgado, Lucía, González, Mónica, Pablos, Tamara, Devesa, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691184/
https://www.ncbi.nlm.nih.gov/pubmed/26703581
http://dx.doi.org/10.3390/ijms161226244
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author Devesa, Jesús
Díaz-Getino, Gustavo
Rey, Pablo
García-Cancela, José
Loures, Iria
Nogueiras, Sonia
Hurtado de Mendoza, Alba
Salgado, Lucía
González, Mónica
Pablos, Tamara
Devesa, Pablo
author_facet Devesa, Jesús
Díaz-Getino, Gustavo
Rey, Pablo
García-Cancela, José
Loures, Iria
Nogueiras, Sonia
Hurtado de Mendoza, Alba
Salgado, Lucía
González, Mónica
Pablos, Tamara
Devesa, Pablo
author_sort Devesa, Jesús
collection PubMed
description The aim of this study is to describe the results obtained after growth hormone (GH) treatment and neurorehabilitation in a young man that suffered a very grave traumatic brain injury (TBI) after a plane crash. Methods: Fifteen months after the accident, the patient was treated with GH, 1 mg/day, at three-month intervals, followed by one-month resting, together with daily neurorehabilitation. Blood analysis at admission showed that no pituitary deficits existed. At admission, the patient presented: spastic tetraplegia, dysarthria, dysphagia, very severe cognitive deficits and joint deformities. Computerized tomography scanners (CT-Scans) revealed the practical loss of the right brain hemisphere and important injuries in the left one. Clinical and blood analysis assessments were performed every three months for three years. Feet surgery was needed because of irreducible equinovarus. Results: Clinical and kinesitherapy assessments revealed a prompt improvement in cognitive functions, dysarthria and dysphagia disappeared and three years later the patient was able to live a practically normal life, walking alone and coming back to his studies. No adverse effects were observed during and after GH administration. Conclusions: These results, together with previous results from our group, indicate that GH treatment is safe and effective for helping neurorehabilitation in TBI patients, once the acute phase is resolved, regardless of whether or not they have GH-deficiency (GHD).
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spelling pubmed-46911842016-01-06 Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report Devesa, Jesús Díaz-Getino, Gustavo Rey, Pablo García-Cancela, José Loures, Iria Nogueiras, Sonia Hurtado de Mendoza, Alba Salgado, Lucía González, Mónica Pablos, Tamara Devesa, Pablo Int J Mol Sci Case Report The aim of this study is to describe the results obtained after growth hormone (GH) treatment and neurorehabilitation in a young man that suffered a very grave traumatic brain injury (TBI) after a plane crash. Methods: Fifteen months after the accident, the patient was treated with GH, 1 mg/day, at three-month intervals, followed by one-month resting, together with daily neurorehabilitation. Blood analysis at admission showed that no pituitary deficits existed. At admission, the patient presented: spastic tetraplegia, dysarthria, dysphagia, very severe cognitive deficits and joint deformities. Computerized tomography scanners (CT-Scans) revealed the practical loss of the right brain hemisphere and important injuries in the left one. Clinical and blood analysis assessments were performed every three months for three years. Feet surgery was needed because of irreducible equinovarus. Results: Clinical and kinesitherapy assessments revealed a prompt improvement in cognitive functions, dysarthria and dysphagia disappeared and three years later the patient was able to live a practically normal life, walking alone and coming back to his studies. No adverse effects were observed during and after GH administration. Conclusions: These results, together with previous results from our group, indicate that GH treatment is safe and effective for helping neurorehabilitation in TBI patients, once the acute phase is resolved, regardless of whether or not they have GH-deficiency (GHD). MDPI 2015-12-21 /pmc/articles/PMC4691184/ /pubmed/26703581 http://dx.doi.org/10.3390/ijms161226244 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Devesa, Jesús
Díaz-Getino, Gustavo
Rey, Pablo
García-Cancela, José
Loures, Iria
Nogueiras, Sonia
Hurtado de Mendoza, Alba
Salgado, Lucía
González, Mónica
Pablos, Tamara
Devesa, Pablo
Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
title Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
title_full Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
title_fullStr Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
title_full_unstemmed Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
title_short Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report
title_sort brain recovery after a plane crash: treatment with growth hormone (gh) and neurorehabilitation: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691184/
https://www.ncbi.nlm.nih.gov/pubmed/26703581
http://dx.doi.org/10.3390/ijms161226244
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