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Reduced cerebellar brain activity during reward processing in adolescent binge drinkers
Due to ongoing development, adolescence may be a period of heightened vulnerability to the neurotoxic effects of alcohol. Binge drinking may alter reward-driven behavior and neurocircuitry, thereby increasing risk for escalating alcohol use. Therefore, we compared reward processing in adolescents wi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691369/ https://www.ncbi.nlm.nih.gov/pubmed/26190276 http://dx.doi.org/10.1016/j.dcn.2015.06.004 |
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author | Cservenka, Anita Jones, Scott A. Nagel, Bonnie J. |
author_facet | Cservenka, Anita Jones, Scott A. Nagel, Bonnie J. |
author_sort | Cservenka, Anita |
collection | PubMed |
description | Due to ongoing development, adolescence may be a period of heightened vulnerability to the neurotoxic effects of alcohol. Binge drinking may alter reward-driven behavior and neurocircuitry, thereby increasing risk for escalating alcohol use. Therefore, we compared reward processing in adolescents with and without a history of recent binge drinking. At their baseline study visit, all participants (age = 14.86 ± 0.88) were free of heavy alcohol use and completed a modified version of the Wheel of Fortune (WOF) functional magnetic resonance imaging task. Following this visit, 17 youth reported binge drinking on ≥3 occasions within a 90 day period and were matched to 17 youth who remained alcohol and substance-naïve. All participants repeated the WOF task during a second visit (age = 16.83 ± 1.22). No significant effects were found in a region of interest analysis of the ventral striatum, but whole-brain analyses showed significant group differences in reward response at the second study visit in the left cerebellum, controlling for baseline visit brain activity (p/α < 0.05), which was negatively correlated with mean number of drinks consumed/drinking day in the last 90 days. These findings suggest that binge drinking during adolescence may alter brain activity during reward processing in a dose-dependent manner. |
format | Online Article Text |
id | pubmed-4691369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-46913692016-12-01 Reduced cerebellar brain activity during reward processing in adolescent binge drinkers Cservenka, Anita Jones, Scott A. Nagel, Bonnie J. Dev Cogn Neurosci Original Research Due to ongoing development, adolescence may be a period of heightened vulnerability to the neurotoxic effects of alcohol. Binge drinking may alter reward-driven behavior and neurocircuitry, thereby increasing risk for escalating alcohol use. Therefore, we compared reward processing in adolescents with and without a history of recent binge drinking. At their baseline study visit, all participants (age = 14.86 ± 0.88) were free of heavy alcohol use and completed a modified version of the Wheel of Fortune (WOF) functional magnetic resonance imaging task. Following this visit, 17 youth reported binge drinking on ≥3 occasions within a 90 day period and were matched to 17 youth who remained alcohol and substance-naïve. All participants repeated the WOF task during a second visit (age = 16.83 ± 1.22). No significant effects were found in a region of interest analysis of the ventral striatum, but whole-brain analyses showed significant group differences in reward response at the second study visit in the left cerebellum, controlling for baseline visit brain activity (p/α < 0.05), which was negatively correlated with mean number of drinks consumed/drinking day in the last 90 days. These findings suggest that binge drinking during adolescence may alter brain activity during reward processing in a dose-dependent manner. Elsevier 2015-06-30 /pmc/articles/PMC4691369/ /pubmed/26190276 http://dx.doi.org/10.1016/j.dcn.2015.06.004 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Cservenka, Anita Jones, Scott A. Nagel, Bonnie J. Reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
title | Reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
title_full | Reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
title_fullStr | Reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
title_full_unstemmed | Reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
title_short | Reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
title_sort | reduced cerebellar brain activity during reward processing in adolescent binge drinkers |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691369/ https://www.ncbi.nlm.nih.gov/pubmed/26190276 http://dx.doi.org/10.1016/j.dcn.2015.06.004 |
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