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HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil

Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with...

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Autores principales: Fancello, Virginia, Melis, Andrea, Piana, Andrea Fausto, Castiglia, Paolo, Cossu, Andrea, Sotgiu, Giovanni, Bozzo, Corrado, King, Emma Victoria, Meloni, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691470/
https://www.ncbi.nlm.nih.gov/pubmed/26783482
http://dx.doi.org/10.1155/2015/916023
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author Fancello, Virginia
Melis, Andrea
Piana, Andrea Fausto
Castiglia, Paolo
Cossu, Andrea
Sotgiu, Giovanni
Bozzo, Corrado
King, Emma Victoria
Meloni, Francesco
author_facet Fancello, Virginia
Melis, Andrea
Piana, Andrea Fausto
Castiglia, Paolo
Cossu, Andrea
Sotgiu, Giovanni
Bozzo, Corrado
King, Emma Victoria
Meloni, Francesco
author_sort Fancello, Virginia
collection PubMed
description Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with HPV types 6 and 18. The tetravalent HPV vaccine Gardasil was prescribed off label, with the aim of triggering an immunogenic response and consequently reducing the probability of further recurrences. The patient was followed for 9 months with no sign of relapse of his LP. The postexposure use of the anti-HPV vaccine could represent a promising therapeutic agent in established LP. Unfortunately, the potential efficacy of this new therapeutic option in this situation has been suggested only by isolated case reports. Further controlled studies, with a longer follow-up and a larger sample size, are needed to assess efficacy of Gardasil in LP.
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spelling pubmed-46914702016-01-18 HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil Fancello, Virginia Melis, Andrea Piana, Andrea Fausto Castiglia, Paolo Cossu, Andrea Sotgiu, Giovanni Bozzo, Corrado King, Emma Victoria Meloni, Francesco Case Rep Otolaryngol Case Report Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with HPV types 6 and 18. The tetravalent HPV vaccine Gardasil was prescribed off label, with the aim of triggering an immunogenic response and consequently reducing the probability of further recurrences. The patient was followed for 9 months with no sign of relapse of his LP. The postexposure use of the anti-HPV vaccine could represent a promising therapeutic agent in established LP. Unfortunately, the potential efficacy of this new therapeutic option in this situation has been suggested only by isolated case reports. Further controlled studies, with a longer follow-up and a larger sample size, are needed to assess efficacy of Gardasil in LP. Hindawi Publishing Corporation 2015 2015-11-29 /pmc/articles/PMC4691470/ /pubmed/26783482 http://dx.doi.org/10.1155/2015/916023 Text en Copyright © 2015 Virginia Fancello et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fancello, Virginia
Melis, Andrea
Piana, Andrea Fausto
Castiglia, Paolo
Cossu, Andrea
Sotgiu, Giovanni
Bozzo, Corrado
King, Emma Victoria
Meloni, Francesco
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
title HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
title_full HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
title_fullStr HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
title_full_unstemmed HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
title_short HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
title_sort hpv type 6 and 18 coinfection in a case of adult-onset laryngeal papillomatosis: immunization with gardasil
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691470/
https://www.ncbi.nlm.nih.gov/pubmed/26783482
http://dx.doi.org/10.1155/2015/916023
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