Diabetic Retinal and Choroidal Edema in SDT Rats

We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diab...

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Autores principales: Toyoda, Fumihiko, Tanaka, Yoshiaki, Shimmura, Machiko, Kinoshita, Nozomi, Takano, Hiroko, Kakehashi, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691483/
https://www.ncbi.nlm.nih.gov/pubmed/26783535
http://dx.doi.org/10.1155/2016/2345141
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author Toyoda, Fumihiko
Tanaka, Yoshiaki
Shimmura, Machiko
Kinoshita, Nozomi
Takano, Hiroko
Kakehashi, Akihiro
author_facet Toyoda, Fumihiko
Tanaka, Yoshiaki
Shimmura, Machiko
Kinoshita, Nozomi
Takano, Hiroko
Kakehashi, Akihiro
author_sort Toyoda, Fumihiko
collection PubMed
description We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diabetes, and 4-micron sections were cut for conventional histopathologic studies. The mean retinal and choroidal thicknesses were significantly thicker in the SDT rats than in the normal SD rats. The choroidal thickness was correlated strongly with the retinal thickness in both rat models. Diabetic retinopathy (DR) and diabetic choroidopathy appeared as edema in the SDT rats. The retinal thickness was correlated strongly with the choroidal thickness in the SDT rats, which is an ideal animal model of both DR and choroidopathy.
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spelling pubmed-46914832016-01-18 Diabetic Retinal and Choroidal Edema in SDT Rats Toyoda, Fumihiko Tanaka, Yoshiaki Shimmura, Machiko Kinoshita, Nozomi Takano, Hiroko Kakehashi, Akihiro J Diabetes Res Research Article We evaluated the features of diabetic retinal and choroidal edema in Spontaneously Diabetic Torii (SDT) rats. We measured the retinal and choroidal thicknesses in normal Sprague-Dawley (SD) rats (n = 9) and SDT rats (n = 8). The eyes were enucleated 40 weeks later after they were diagnosed with diabetes, and 4-micron sections were cut for conventional histopathologic studies. The mean retinal and choroidal thicknesses were significantly thicker in the SDT rats than in the normal SD rats. The choroidal thickness was correlated strongly with the retinal thickness in both rat models. Diabetic retinopathy (DR) and diabetic choroidopathy appeared as edema in the SDT rats. The retinal thickness was correlated strongly with the choroidal thickness in the SDT rats, which is an ideal animal model of both DR and choroidopathy. Hindawi Publishing Corporation 2016 2015-12-13 /pmc/articles/PMC4691483/ /pubmed/26783535 http://dx.doi.org/10.1155/2016/2345141 Text en Copyright © 2016 Fumihiko Toyoda et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Toyoda, Fumihiko
Tanaka, Yoshiaki
Shimmura, Machiko
Kinoshita, Nozomi
Takano, Hiroko
Kakehashi, Akihiro
Diabetic Retinal and Choroidal Edema in SDT Rats
title Diabetic Retinal and Choroidal Edema in SDT Rats
title_full Diabetic Retinal and Choroidal Edema in SDT Rats
title_fullStr Diabetic Retinal and Choroidal Edema in SDT Rats
title_full_unstemmed Diabetic Retinal and Choroidal Edema in SDT Rats
title_short Diabetic Retinal and Choroidal Edema in SDT Rats
title_sort diabetic retinal and choroidal edema in sdt rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691483/
https://www.ncbi.nlm.nih.gov/pubmed/26783535
http://dx.doi.org/10.1155/2016/2345141
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AT shimmuramachiko diabeticretinalandchoroidaledemainsdtrats
AT kinoshitanozomi diabeticretinalandchoroidaledemainsdtrats
AT takanohiroko diabeticretinalandchoroidaledemainsdtrats
AT kakehashiakihiro diabeticretinalandchoroidaledemainsdtrats

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