Cargando…

Cholesterol Enhances the Toxic Effect of Ethanol and Acetaldehyde in Primary Mouse Hepatocytes

Obesity and alcohol consumption are risk factors for hepatic steatosis, and both commonly coexist. Our objective was to evaluate the effect of ethanol and acetaldehyde on primary hepatocytes obtained from mice fed for two days with a high cholesterol (HC) diet. HC hepatocytes increased lipid and cho...

Descripción completa

Detalles Bibliográficos
Autores principales:	López-Islas, Anayelly, Chagoya-Hazas, Victoria, Pérez-Aguilar, Benjamin, Palestino-Domínguez, Mayrel, Souza, Verónica, Miranda, Roxana U., Bucio, Leticia, Gómez-Quiroz, Luis Enrique, Gutiérrez-Ruiz, María-Concepción
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691636/ https://www.ncbi.nlm.nih.gov/pubmed/26788255 http://dx.doi.org/10.1155/2016/9209825

Ejemplares similares

Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress
por: Domínguez-Pérez, Mayra, et al.
Publicado: (2016)

Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci
por: Xu, Jian, et al.
Publicado: (2021)

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice
por: Nuño-Lámbarri, Natalia, et al.
Publicado: (2016)

Decarboxylation of Pyruvate to Acetaldehyde for Ethanol Production by Hyperthermophiles
por: Eram, Mohammad S., et al.
Publicado: (2013)

Acetaldehyde mediates the ethanol effects in developing brain
por: Zimatkin, S. M.
Publicado: (2013)

Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
por: Skorupan, Nebojsa, et al.
Publicado: (2022)

The Role of Acetaldehyde in the Increased Acceptance of Ethanol after Prenatal Ethanol Exposure
por: Gaztañaga, Mirari, et al.
Publicado: (2017)

Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis
por: Enríquez-Cortina, Cristina, et al.
Publicado: (2017)

On the Accuracy of In Vivo Ethanol and Acetaldehyde Monitoring, a Key Tile in the Puzzle of Acetaldehyde as a Neuroactive Agent
por: Enrico, Paolo, et al.
Publicado: (2017)

Gene specific modifications unravel ethanol and acetaldehyde actions
por: Israel, Yedy, et al.
Publicado: (2013)

The Involvement of Acetaldehyde in Ethanol-Induced Cell Cycle Impairment
por: Scheer, Marc A., et al.
Publicado: (2016)

The Consumption of Cholesterol-Enriched Diets Conditions the Development of a Subtype of HCC with High Aggressiveness and Poor Prognosis
por: Simoni-Nieves, Arturo, et al.
Publicado: (2021)

Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny
por: March, Samanta M., et al.
Publicado: (2013)

Ethanol-derived acetaldehyde: pleasure and pain of alcohol mechanism of action
por: Muggironi, Giulia, et al.
Publicado: (2013)

Behavioral and biochemical evidence of the role of acetaldehyde in the motivational effects of ethanol
por: Peana, Alessandra T., et al.
Publicado: (2013)

The effect of ethanol and acetaldehyde on brain ependymal and respiratory ciliary beat frequency
por: Smith, Claire Mary, et al.
Publicado: (2013)

Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde
por: Font, Laura, et al.
Publicado: (2013)

Acetaldehyde as an Intermediate in the Electroreduction of Carbon Monoxide to Ethanol on Oxide‐Derived Copper
por: Bertheussen, Erlend, et al.
Publicado: (2015)

Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates
por: Pandya, H. C., et al.
Publicado: (2016)

GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies
por: Simoni-Nieves, Arturo, et al.
Publicado: (2019)

Metabolic property of acetaldehyde production from ethanol and glucose by oral Streptococcus and Neisseria
por: Tagaino, Ryo, et al.
Publicado: (2019)

Role of Acetaldehyde in Ethanol Reversal of Tolerance to Morphine-Induced Respiratory Depression in Mice
por: Hill, Rob, et al.
Publicado: (2022)

Production of Acetaldehyde via Oxidative Dehydrogenation of Ethanol in a Chemical Looping Setup
por: Gebers, Joseph C., et al.
Publicado: (2023)

Bifacial biological effects of ethanol: acetaldehyde production by oral Streptococcus species and the antibacterial effects of ethanol against these bacteria
por: Tagaino, Ryo, et al.
Publicado: (2021)

Acetaldehyde in the Enders triple cascade reaction via acetaldehyde dimethyl acetal
por: Brusa, Alessandro, et al.
Publicado: (2023)

An original method for producing acetaldehyde and diacetyl by yeast fermentation
por: Rosca, Irina, et al.
Publicado: (2016)

Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity
por: Bootorabi, Fatemeh, et al.
Publicado: (2008)

ALDH2 Genotype Has No Effect on Salivary Acetaldehyde without the Presence of Ethanol in the Systemic Circulation
por: Helminen, Andreas, et al.
Publicado: (2013)

Replacement of the initial steps of ethanol metabolism in Saccharomyces cerevisiae by ATP-independent acetylating acetaldehyde dehydrogenase
por: Kozak, Barbara U., et al.
Publicado: (2016)

Brain Acetaldehyde Exposure Impacts upon Neonatal Respiratory Plasticity and Ethanol-Related Learning in Rodents
por: Acevedo, María B., et al.
Publicado: (2017)

Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake
por: D’aloisio, Genesis, et al.
Publicado: (2022)

Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver
por: Zhong, Shanshan, et al.
Publicado: (2021)

Acetaldehyde-ethanol interactions on calcium-activated potassium (BK) channels in pituitary tumor (GH3) cells
por: Handlechner, Astrid G., et al.
Publicado: (2013)

Detrimental Effects of Ethanol and Its Metabolite Acetaldehyde, on First Trimester Human Placental Cell Turnover and Function
por: Lui, Sylvia, et al.
Publicado: (2014)

Folate Metabolism in Hepatocellular Carcinoma. What Do We Know So Far?
por: Quevedo-Ocampo, Jaqueline, et al.
Publicado: (2022)

Determination of Methanol, Acetaldehyde, and Ethyl Acetate in Thousand Folds of Ethanol Sample by Headspace Gas Chromatography with Mass Spectrometry
por: Thang, Nguyen Quoc, et al.
Publicado: (2023)

Polyphenols from persimmon fruit attenuate acetaldehyde-induced DNA double-strand breaks by scavenging acetaldehyde
por: Matsuzaki, Kenichiro, et al.
Publicado: (2022)

Ethanol and acetaldehyde mediate folic acid and human papillomavirus-induced proliferation of oral squamous cell carcinoma cells in vitro
por: Kingsley, Karl, et al.
Publicado: (2012)

Ethanol Dehydrogenase I Contributes to Growth and Sporulation Under Low Oxygen Condition via Detoxification of Acetaldehyde in Metarhizium acridum
por: Zhang, Erhao, et al.
Publicado: (2018)

Acetaldehyde adducts in alcoholic liver disease
por: Setshedi, Mashiko, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_f1c3ha2to6uh1318h1ui76rgq3