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Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population

Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been...

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Autores principales: Lange, Johannes, Lunde, Kristin Aaser, Sletten, Camilla, Møller, Simon Geir, Tysnes, Ole-Bjørn, Alves, Guido, Larsen, Jan Petter, Maple-Grødem, Jodi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691638/
https://www.ncbi.nlm.nih.gov/pubmed/26788404
http://dx.doi.org/10.1155/2015/973298
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author Lange, Johannes
Lunde, Kristin Aaser
Sletten, Camilla
Møller, Simon Geir
Tysnes, Ole-Bjørn
Alves, Guido
Larsen, Jan Petter
Maple-Grødem, Jodi
author_facet Lange, Johannes
Lunde, Kristin Aaser
Sletten, Camilla
Møller, Simon Geir
Tysnes, Ole-Bjørn
Alves, Guido
Larsen, Jan Petter
Maple-Grødem, Jodi
author_sort Lange, Johannes
collection PubMed
description Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.
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spelling pubmed-46916382016-01-19 Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population Lange, Johannes Lunde, Kristin Aaser Sletten, Camilla Møller, Simon Geir Tysnes, Ole-Bjørn Alves, Guido Larsen, Jan Petter Maple-Grødem, Jodi Parkinsons Dis Research Article Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD. Hindawi Publishing Corporation 2015 2015-12-14 /pmc/articles/PMC4691638/ /pubmed/26788404 http://dx.doi.org/10.1155/2015/973298 Text en Copyright © 2015 Johannes Lange et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lange, Johannes
Lunde, Kristin Aaser
Sletten, Camilla
Møller, Simon Geir
Tysnes, Ole-Bjørn
Alves, Guido
Larsen, Jan Petter
Maple-Grødem, Jodi
Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
title Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
title_full Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
title_fullStr Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
title_full_unstemmed Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
title_short Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
title_sort association of a bace1 gene polymorphism with parkinson's disease in a norwegian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691638/
https://www.ncbi.nlm.nih.gov/pubmed/26788404
http://dx.doi.org/10.1155/2015/973298
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