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Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population
Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691638/ https://www.ncbi.nlm.nih.gov/pubmed/26788404 http://dx.doi.org/10.1155/2015/973298 |
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author | Lange, Johannes Lunde, Kristin Aaser Sletten, Camilla Møller, Simon Geir Tysnes, Ole-Bjørn Alves, Guido Larsen, Jan Petter Maple-Grødem, Jodi |
author_facet | Lange, Johannes Lunde, Kristin Aaser Sletten, Camilla Møller, Simon Geir Tysnes, Ole-Bjørn Alves, Guido Larsen, Jan Petter Maple-Grødem, Jodi |
author_sort | Lange, Johannes |
collection | PubMed |
description | Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD. |
format | Online Article Text |
id | pubmed-4691638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46916382016-01-19 Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population Lange, Johannes Lunde, Kristin Aaser Sletten, Camilla Møller, Simon Geir Tysnes, Ole-Bjørn Alves, Guido Larsen, Jan Petter Maple-Grødem, Jodi Parkinsons Dis Research Article Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD. Hindawi Publishing Corporation 2015 2015-12-14 /pmc/articles/PMC4691638/ /pubmed/26788404 http://dx.doi.org/10.1155/2015/973298 Text en Copyright © 2015 Johannes Lange et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lange, Johannes Lunde, Kristin Aaser Sletten, Camilla Møller, Simon Geir Tysnes, Ole-Bjørn Alves, Guido Larsen, Jan Petter Maple-Grødem, Jodi Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population |
title | Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population |
title_full | Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population |
title_fullStr | Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population |
title_full_unstemmed | Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population |
title_short | Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population |
title_sort | association of a bace1 gene polymorphism with parkinson's disease in a norwegian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691638/ https://www.ncbi.nlm.nih.gov/pubmed/26788404 http://dx.doi.org/10.1155/2015/973298 |
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