An Evaluation of Systemic Vancomycin Dosing in Obese Patients

We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more...

Descripción completa

Detalles Bibliográficos
Autores principales: Kubiak, David W., Alquwaizani, Mohammed, Sansonetti, David, Barra, Megan E., Calderwood, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691676/
https://www.ncbi.nlm.nih.gov/pubmed/26716105
http://dx.doi.org/10.1093/ofid/ofv176
_version_ 1782407179086594048
author Kubiak, David W.
Alquwaizani, Mohammed
Sansonetti, David
Barra, Megan E.
Calderwood, Michael S.
author_facet Kubiak, David W.
Alquwaizani, Mohammed
Sansonetti, David
Barra, Megan E.
Calderwood, Michael S.
author_sort Kubiak, David W.
collection PubMed
description We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL.
format Online
Article
Text
id pubmed-4691676
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-46916762015-12-29 An Evaluation of Systemic Vancomycin Dosing in Obese Patients Kubiak, David W. Alquwaizani, Mohammed Sansonetti, David Barra, Megan E. Calderwood, Michael S. Open Forum Infect Dis Brief Reports We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL. Oxford University Press 2015-11-13 /pmc/articles/PMC4691676/ /pubmed/26716105 http://dx.doi.org/10.1093/ofid/ofv176 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Kubiak, David W.
Alquwaizani, Mohammed
Sansonetti, David
Barra, Megan E.
Calderwood, Michael S.
An Evaluation of Systemic Vancomycin Dosing in Obese Patients
title An Evaluation of Systemic Vancomycin Dosing in Obese Patients
title_full An Evaluation of Systemic Vancomycin Dosing in Obese Patients
title_fullStr An Evaluation of Systemic Vancomycin Dosing in Obese Patients
title_full_unstemmed An Evaluation of Systemic Vancomycin Dosing in Obese Patients
title_short An Evaluation of Systemic Vancomycin Dosing in Obese Patients
title_sort evaluation of systemic vancomycin dosing in obese patients
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691676/
https://www.ncbi.nlm.nih.gov/pubmed/26716105
http://dx.doi.org/10.1093/ofid/ofv176
work_keys_str_mv AT kubiakdavidw anevaluationofsystemicvancomycindosinginobesepatients
AT alquwaizanimohammed anevaluationofsystemicvancomycindosinginobesepatients
AT sansonettidavid anevaluationofsystemicvancomycindosinginobesepatients
AT barramegane anevaluationofsystemicvancomycindosinginobesepatients
AT calderwoodmichaels anevaluationofsystemicvancomycindosinginobesepatients
AT kubiakdavidw evaluationofsystemicvancomycindosinginobesepatients
AT alquwaizanimohammed evaluationofsystemicvancomycindosinginobesepatients
AT sansonettidavid evaluationofsystemicvancomycindosinginobesepatients
AT barramegane evaluationofsystemicvancomycindosinginobesepatients
AT calderwoodmichaels evaluationofsystemicvancomycindosinginobesepatients

Ejemplares similares