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An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions

Biological catalysis hinges on the precise structural integrity of an active site that binds and transforms its substrates and meeting this requirement presents a unique challenge for RNA enzymes. Functional RNAs, including ribozymes, fold into their active conformations within rugged energy landsca...

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Detalles Bibliográficos
Autores principales:	Sengupta, Raghuvir N., Van Schie, Sabine N.S., Giambaşu, George, Dai, Qing, Yesselman, Joseph D., York, Darrin, Piccirilli, Joseph A., Herschlag, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691833/ https://www.ncbi.nlm.nih.gov/pubmed/26567314 http://dx.doi.org/10.1261/rna.053710.115

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